Research progress on the pharmacological effects of berberine targeting mitochondria
Berberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis, which interacts with multiple intracellular targets and exhibits a wide range of pharmacological activities. Previous studies have preliminarily confirmed that the regulation of mitochondrial activity is related...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.982145/full |
| _version_ | 1828749611668340736 |
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| author | Xinyi Fang Xinyi Fang Haoran Wu Jiahua Wei Runyu Miao Runyu Miao Yanjiao Zhang Jiaxing Tian |
| author_facet | Xinyi Fang Xinyi Fang Haoran Wu Jiahua Wei Runyu Miao Runyu Miao Yanjiao Zhang Jiaxing Tian |
| author_sort | Xinyi Fang |
| collection | DOAJ |
| description | Berberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis, which interacts with multiple intracellular targets and exhibits a wide range of pharmacological activities. Previous studies have preliminarily confirmed that the regulation of mitochondrial activity is related to various pharmacological actions of berberine, such as regulating blood sugar and lipid and inhibiting tumor progression. However, the mechanism of berberine’s regulation of mitochondrial activity remains to be further studied. This paper summarizes the molecular mechanism of the mitochondrial quality control system and briefly reviews the targets of berberine in regulating mitochondrial activity. It is proposed that berberine mainly regulates glycolipid metabolism by regulating mitochondrial respiratory chain function, promotes tumor cell apoptosis by regulating mitochondrial apoptosis pathway, and protects cardiac function by promoting mitophagy to alleviate mitochondrial dysfunction. It reveals the mechanism of berberine’s pharmacological effects from the perspective of mitochondria and provides a scientific basis for the application of berberine in the clinical treatment of diseases. |
| first_indexed | 2024-12-10T20:24:35Z |
| format | Article |
| id | doaj.art-2c4dcba4ffb549588162d4bbe6d5c20b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T20:24:35Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2c4dcba4ffb549588162d4bbe6d5c20b2022-12-22T01:34:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.982145982145Research progress on the pharmacological effects of berberine targeting mitochondriaXinyi Fang0Xinyi Fang1Haoran Wu2Jiahua Wei3Runyu Miao4Runyu Miao5Yanjiao Zhang6Jiaxing Tian7Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate College, Beijing University of Chinese Medicine, Beijing, ChinaGraduate College, Beijing University of Chinese Medicine, Beijing, ChinaGraduate College, Changchun University of Chinese Medicine, Changchun, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate College, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBerberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis, which interacts with multiple intracellular targets and exhibits a wide range of pharmacological activities. Previous studies have preliminarily confirmed that the regulation of mitochondrial activity is related to various pharmacological actions of berberine, such as regulating blood sugar and lipid and inhibiting tumor progression. However, the mechanism of berberine’s regulation of mitochondrial activity remains to be further studied. This paper summarizes the molecular mechanism of the mitochondrial quality control system and briefly reviews the targets of berberine in regulating mitochondrial activity. It is proposed that berberine mainly regulates glycolipid metabolism by regulating mitochondrial respiratory chain function, promotes tumor cell apoptosis by regulating mitochondrial apoptosis pathway, and protects cardiac function by promoting mitophagy to alleviate mitochondrial dysfunction. It reveals the mechanism of berberine’s pharmacological effects from the perspective of mitochondria and provides a scientific basis for the application of berberine in the clinical treatment of diseases.https://www.frontiersin.org/articles/10.3389/fendo.2022.982145/fullberberinemitochondriapharmacological actionglycolipid metabolism disordertumorcardiovascular diseases |
| spellingShingle | Xinyi Fang Xinyi Fang Haoran Wu Jiahua Wei Runyu Miao Runyu Miao Yanjiao Zhang Jiaxing Tian Research progress on the pharmacological effects of berberine targeting mitochondria Frontiers in Endocrinology berberine mitochondria pharmacological action glycolipid metabolism disorder tumor cardiovascular diseases |
| title | Research progress on the pharmacological effects of berberine targeting mitochondria |
| title_full | Research progress on the pharmacological effects of berberine targeting mitochondria |
| title_fullStr | Research progress on the pharmacological effects of berberine targeting mitochondria |
| title_full_unstemmed | Research progress on the pharmacological effects of berberine targeting mitochondria |
| title_short | Research progress on the pharmacological effects of berberine targeting mitochondria |
| title_sort | research progress on the pharmacological effects of berberine targeting mitochondria |
| topic | berberine mitochondria pharmacological action glycolipid metabolism disorder tumor cardiovascular diseases |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.982145/full |
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