Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension
A variety of cell types in pulmonary arteries (endothelial cells, fibroblasts, and smooth muscle cells) are continuously exposed to mechanical stimulations such as shear stress and pulsatile blood pressure, which are altered under conditions of pulmonary hypertension (PH). Most functions of such vas...
Main Authors: | Solène Barbeau, Guillaume Gilbert, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Pierre Vacher, Jean-François Quignard, Thomas Ducret |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/9/1389 |
Similar Items
-
Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca<sup>2+</sup> Influx and Akt-eNOS Pathway
by: Thais Porto Ribeiro, et al.
Published: (2022-07-01) -
Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism
by: Clément Bouchet, et al.
Published: (2022-09-01) -
NiONP-Induced Oxidative Stress and Mitochondrial Impairment in an In Vitro Pulmonary Vascular Cell Model Mimicking Endothelial Dysfunction
by: Ophélie Germande, et al.
Published: (2022-04-01) -
Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia
by: Solène Barbeau, et al.
Published: (2022-07-01) -
The Role of Regulatory T Cells in Pulmonary Arterial Hypertension
by: Haihua Qiu, et al.
Published: (2019-12-01)