Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck

Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck

IntroductionCutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion (PNI) and spread (PNS). An in vivo sciatic nerve mouse model is used for cSCCHN PNI/PNS....

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Bibliographic Details
Main Authors: Priscila O. de Lima, Natasa Broit, Johnson D. Huang, Jae H. Lim, Damien J. Gardiner, Ian S. Brown, Benedict J. Panizza, Glen M. Boyle, Fiona Simpson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
perineural invasion
perineural spread
cutaneous SCC of the head and neck
in vivo mouse models
LOXL2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1231104/full

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