Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts
The goal of this study was the evaluation of antifungal, antioxidant and anticancer potentials of Pleurotus eryngii, P. ostreatus and P. pulmonarius mycelial extracts, and the influence of mycelium enrichment with selenium on these activities. Both Se-amended and non-amended extracts showed...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641404379M.pdf |
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| author | Milovanović Ivan Stajić Mirjana Ćilerdžić Jasmina Stanojković Tatjana Knežević Aleksandar Vukojević Jelena |
| author_facet | Milovanović Ivan Stajić Mirjana Ćilerdžić Jasmina Stanojković Tatjana Knežević Aleksandar Vukojević Jelena |
| author_sort | Milovanović Ivan |
| collection | DOAJ |
| description | The goal of this study was the evaluation of antifungal, antioxidant and
anticancer potentials of Pleurotus eryngii, P. ostreatus and P. pulmonarius
mycelial extracts, and the influence of mycelium enrichment with selenium on
these activities. Both Se-amended and non-amended extracts showed the same
or similar minimal inhibitory concentration for 14 studied micromycetes,
while a fungicidal effect was not noted, contrary to ketoconazole, which had
inhibitory and fungicidal effects at very low concentrations. Se-non-amended
extracts exhibited antioxidant activity, especially at higher
concentrations. Selenium enrichment influenced activity, its effects
decreasing in P. eryngii and P. pulmonarius, while in P. ostreatus no effect
was noted. The DPPH• radical scavenging capacity of the extracts was in
direct correlation with their phenol and flavonoid contents. Cytotoxic
activity against both HeLa and LS174 cell lines was very low compared with
cis-DDP. These features suggest that mycelium should be an object of
intensive studies. [Projekat Ministarstva nauke Republike Srbije, br. 173032] |
| first_indexed | 2024-12-21T20:55:46Z |
| format | Article |
| id | doaj.art-2c50ae95fdd141cfa7be200ea8258f7f |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-21T20:55:46Z |
| publishDate | 2014-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-2c50ae95fdd141cfa7be200ea8258f7f2022-12-21T18:50:36ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-016641379138810.2298/ABS1404379M0354-46641404379MAntioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extractsMilovanović Ivan0Stajić Mirjana1Ćilerdžić Jasmina2Stanojković Tatjana3Knežević Aleksandar4Vukojević Jelena5Faculty of Biology, BelgradeFaculty of Biology, BelgradeFaculty of Biology, BelgradeInstitute of Oncology and Radiology of Serbia, BelgradeFaculty of Biology, BelgradeFaculty of Biology, BelgradeThe goal of this study was the evaluation of antifungal, antioxidant and anticancer potentials of Pleurotus eryngii, P. ostreatus and P. pulmonarius mycelial extracts, and the influence of mycelium enrichment with selenium on these activities. Both Se-amended and non-amended extracts showed the same or similar minimal inhibitory concentration for 14 studied micromycetes, while a fungicidal effect was not noted, contrary to ketoconazole, which had inhibitory and fungicidal effects at very low concentrations. Se-non-amended extracts exhibited antioxidant activity, especially at higher concentrations. Selenium enrichment influenced activity, its effects decreasing in P. eryngii and P. pulmonarius, while in P. ostreatus no effect was noted. The DPPH• radical scavenging capacity of the extracts was in direct correlation with their phenol and flavonoid contents. Cytotoxic activity against both HeLa and LS174 cell lines was very low compared with cis-DDP. These features suggest that mycelium should be an object of intensive studies. [Projekat Ministarstva nauke Republike Srbije, br. 173032]http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641404379M.pdfBiological activitiesPleurotus eryngiiP. ostreatusP. pulmonariusselenium |
| spellingShingle | Milovanović Ivan Stajić Mirjana Ćilerdžić Jasmina Stanojković Tatjana Knežević Aleksandar Vukojević Jelena Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts Archives of Biological Sciences Biological activities Pleurotus eryngii P. ostreatus P. pulmonarius selenium |
| title | Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts |
| title_full | Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts |
| title_fullStr | Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts |
| title_full_unstemmed | Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts |
| title_short | Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts |
| title_sort | antioxidant antifungal and anticancer activities of se enriched pleurotus spp mycelium extracts |
| topic | Biological activities Pleurotus eryngii P. ostreatus P. pulmonarius selenium |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641404379M.pdf |
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