Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study
Background/Aims We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females. Methods The study data were collected from a general health examination and questionnaire survey of eligible populations conducted b...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-05-01
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| Series: | The Korean Journal of Internal Medicine |
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| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-283.pdf |
| _version_ | 1819112514396356608 |
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| author | Yoon Ho Ko Seung Joon Kim Wan-Seop Kim Chan Kwon Park Cheol-Kyu Park Yang-Gun Suh Jung Seop Eom Sukki Cho Jae Young Hur Sung Ho Hwang Jun-Pyo Myong |
| author_facet | Yoon Ho Ko Seung Joon Kim Wan-Seop Kim Chan Kwon Park Cheol-Kyu Park Yang-Gun Suh Jung Seop Eom Sukki Cho Jae Young Hur Sung Ho Hwang Jun-Pyo Myong |
| author_sort | Yoon Ho Ko |
| collection | DOAJ |
| description | Background/Aims We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females. Methods The study data were collected from a general health examination and questionnaire survey of eligible populations conducted between January 1, 2003 and December 31, 2004; the data were acquired from the tailored big data distribution service of the National Health Insurance Service. After a 1-year clearance period, 5,860,922 of 6,318,878 never-smoking female participants with no previous history of lung cancer were investigated. After a median follow-up of 11.4 years, 43,473 (0.74%) participants were defined as “newly diagnosed lung cancer”. Results After adjusting for all variables at baseline, the variables older age, lower body mass index (BMI), less exercise, frequent alcohol drinking, meat-based diet, rural residence, and previous history of cancer were associated with a higher incidence of lung cancer. Low BMI (< 18.5 kg/m2: hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.27 to 1.40) was a significant independent risk factor; as BMI decreased, HR increased. Negative associations between BMI and lung-cancer development were also observed after controlling for age (p for trend < 0.001). Drinking alcohol one to two times a week (HR, 1.25; 95% CI, 1.21 to 1.28) and eating a meat-based diet (HR, 1.08; 95% CI, 1.01 to 1.15) were associated with lung-cancer incidence. Conclusions Modifiable baseline characteristics, such as BMI, exercise, alcohol consumption, and diet, are risk factors for lung-cancer development among never- smoking females. Thus, lifestyle modifications may help prevent lung cancer. |
| first_indexed | 2024-12-22T04:14:43Z |
| format | Article |
| id | doaj.art-2c50f41e0c4f48a79ba6a9e36a7ff4bd |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T04:14:43Z |
| publishDate | 2020-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-2c50f41e0c4f48a79ba6a9e36a7ff4bd2022-12-21T18:39:26ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-05-0135369270210.3904/kjim.2019.283170306Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort studyYoon Ho Ko0Seung Joon Kim1Wan-Seop Kim2Chan Kwon Park3Cheol-Kyu Park4Yang-Gun Suh5Jung Seop Eom6Sukki Cho7Jae Young Hur8Sung Ho Hwang9Jun-Pyo Myong10 Division of Oncology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Pulmonology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Pathology, Konkuk University Medical Center, Seoul, Korea Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea Department of Radiation Oncology, National Cancer Center, Goyang, Korea Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pathology, Konkuk University Medical Center, Seoul, Korea Department of Radiology, Korea University Anam Hospital, Seoul, Korea Department of Occupational and Environmental Medicine, Seoul St. Mary’s Hospital, of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females. Methods The study data were collected from a general health examination and questionnaire survey of eligible populations conducted between January 1, 2003 and December 31, 2004; the data were acquired from the tailored big data distribution service of the National Health Insurance Service. After a 1-year clearance period, 5,860,922 of 6,318,878 never-smoking female participants with no previous history of lung cancer were investigated. After a median follow-up of 11.4 years, 43,473 (0.74%) participants were defined as “newly diagnosed lung cancer”. Results After adjusting for all variables at baseline, the variables older age, lower body mass index (BMI), less exercise, frequent alcohol drinking, meat-based diet, rural residence, and previous history of cancer were associated with a higher incidence of lung cancer. Low BMI (< 18.5 kg/m2: hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.27 to 1.40) was a significant independent risk factor; as BMI decreased, HR increased. Negative associations between BMI and lung-cancer development were also observed after controlling for age (p for trend < 0.001). Drinking alcohol one to two times a week (HR, 1.25; 95% CI, 1.21 to 1.28) and eating a meat-based diet (HR, 1.08; 95% CI, 1.01 to 1.15) were associated with lung-cancer incidence. Conclusions Modifiable baseline characteristics, such as BMI, exercise, alcohol consumption, and diet, are risk factors for lung-cancer development among never- smoking females. Thus, lifestyle modifications may help prevent lung cancer.http://www.kjim.org/upload/pdf/kjim-2019-283.pdflung neoplasmnever-smoking womenrisk factorcohort studies |
| spellingShingle | Yoon Ho Ko Seung Joon Kim Wan-Seop Kim Chan Kwon Park Cheol-Kyu Park Yang-Gun Suh Jung Seop Eom Sukki Cho Jae Young Hur Sung Ho Hwang Jun-Pyo Myong Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study The Korean Journal of Internal Medicine lung neoplasm never-smoking women risk factor cohort studies |
| title | Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study |
| title_full | Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study |
| title_fullStr | Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study |
| title_full_unstemmed | Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study |
| title_short | Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study |
| title_sort | risk factors for primary lung cancer among never smoking women in south korea a retrospective nationwide population based cohort study |
| topic | lung neoplasm never-smoking women risk factor cohort studies |
| url | http://www.kjim.org/upload/pdf/kjim-2019-283.pdf |
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