Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies

Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies

Pentraxin-3 (PTX3) and C-reactive protein (CRP) have been shown to regulate complement activation in vitro, but their role has not been investigated in complement consumption in vivo. Thrombotic microangiopathies (TMA) are often accompanied by complement overactivation and consumption, therefore we...

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Bibliographic Details
Main Authors: Eszter Trojnar, Mihály Józsi, Zsóka Szabó, Marienn Réti, Péter Farkas, Kata Kelen, George S. Reusz, Attila J. Szabó, Nóra Garam, Bálint Mikes, György Sinkovits, Blanka Mező, Dorottya Csuka, Zoltán Prohászka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
pentraxin-3
C-reactive protein
thrombotic microangiopathies
hemolytic uremic syndrome
thrombotic thrombocytopenic purpura
alternative pathway
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00240/full

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