Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society
The growing use of biological drugs in immune-mediated chronic diseases has undoubtedly revolutionized their treatment. Yet, the topic of vaccinations in this group of patients still raises many concerns and implies many therapeutic problems that require discussion and standardization of management....
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MDPI AG
2024-01-01
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Series: | Vaccines |
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Online Access: | https://www.mdpi.com/2076-393X/12/1/82 |
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author | Joanna Narbutt Zbigniew Żuber Aleksandra Lesiak Natalia Bień Jacek C. Szepietowski |
author_facet | Joanna Narbutt Zbigniew Żuber Aleksandra Lesiak Natalia Bień Jacek C. Szepietowski |
author_sort | Joanna Narbutt |
collection | DOAJ |
description | The growing use of biological drugs in immune-mediated chronic diseases has undoubtedly revolutionized their treatment. Yet, the topic of vaccinations in this group of patients still raises many concerns and implies many therapeutic problems that require discussion and standardization of management. The aim of this literature review is to present current knowledge regarding safety and efficacy of vaccinations in dermatological and rheumatological patients treated with biological drugs and JAK inhibitors. Additionally, this article provides recommendation from experts of the Polish Dermatological Society about proper use of vaccinations during therapy with biologics. Generally, all live attenuated vaccines are contraindicated during immunosuppressive/immunomodulatory therapy. If there is need, they should be administered long enough prior to the therapy or after cessation. Yet, inactivated vaccines mostly can be safely used, but the problem in this case is the effectiveness of the vaccination. Most studies report that the immune response in patients on biologics after administration of different inactivated vaccines is similar to or even better than in the control group. Thus, the importance of vaccination among patients on biologics must be emphasized to reduce omissions and the fear of possible side effects or insufficient post-vaccination response. |
first_indexed | 2024-03-08T09:44:25Z |
format | Article |
id | doaj.art-2c586e98b5a04706aa30e1ef7364361c |
institution | Directory Open Access Journal |
issn | 2076-393X |
language | English |
last_indexed | 2024-03-08T09:44:25Z |
publishDate | 2024-01-01 |
publisher | MDPI AG |
record_format | Article |
series | Vaccines |
spelling | doaj.art-2c586e98b5a04706aa30e1ef7364361c2024-01-29T14:25:57ZengMDPI AGVaccines2076-393X2024-01-011218210.3390/vaccines12010082Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological SocietyJoanna Narbutt0Zbigniew Żuber1Aleksandra Lesiak2Natalia Bień3Jacek C. Szepietowski4Department of Dermatology, Pediatric Dermatology and Oncology Clinic, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, PolandDepartment of Dermatology, Pediatric Dermatology and Oncology Clinic, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Dermatology, Pediatric Dermatology and Oncology Clinic, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, PolandThe growing use of biological drugs in immune-mediated chronic diseases has undoubtedly revolutionized their treatment. Yet, the topic of vaccinations in this group of patients still raises many concerns and implies many therapeutic problems that require discussion and standardization of management. The aim of this literature review is to present current knowledge regarding safety and efficacy of vaccinations in dermatological and rheumatological patients treated with biological drugs and JAK inhibitors. Additionally, this article provides recommendation from experts of the Polish Dermatological Society about proper use of vaccinations during therapy with biologics. Generally, all live attenuated vaccines are contraindicated during immunosuppressive/immunomodulatory therapy. If there is need, they should be administered long enough prior to the therapy or after cessation. Yet, inactivated vaccines mostly can be safely used, but the problem in this case is the effectiveness of the vaccination. Most studies report that the immune response in patients on biologics after administration of different inactivated vaccines is similar to or even better than in the control group. Thus, the importance of vaccination among patients on biologics must be emphasized to reduce omissions and the fear of possible side effects or insufficient post-vaccination response.https://www.mdpi.com/2076-393X/12/1/82vaccinationbiological drugsJAK inhibitorsimmunizationvaccinebiologics |
spellingShingle | Joanna Narbutt Zbigniew Żuber Aleksandra Lesiak Natalia Bień Jacek C. Szepietowski Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society Vaccines vaccination biological drugs JAK inhibitors immunization vaccine biologics |
title | Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society |
title_full | Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society |
title_fullStr | Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society |
title_full_unstemmed | Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society |
title_short | Vaccinations in Selected Immune-Related Diseases Treated with Biological Drugs and JAK Inhibitors—Literature Review and Statement of Experts from Polish Dermatological Society |
title_sort | vaccinations in selected immune related diseases treated with biological drugs and jak inhibitors literature review and statement of experts from polish dermatological society |
topic | vaccination biological drugs JAK inhibitors immunization vaccine biologics |
url | https://www.mdpi.com/2076-393X/12/1/82 |
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