A new duet in cancer biology: AMPK the typical and UBE2O the atypical

A new duet in cancer biology: AMPK the typical and UBE2O the atypical

Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1–hypoxia-inducible factor 1-α pathway. Critically, UBE2O targe...

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Bibliographic Details
Main Authors:	Isabelle K. Vila, Su Jung Song, Min Sup Song
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-05-01
Series:	Molecular & Cellular Oncology
Subjects:	ampk ampkα2 arsenite breast cancer cancer metabolism hif1α mtor prostate cancer ube2o ubiquitination
Online Access:	http://dx.doi.org/10.1080/23723556.2017.1304846

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