Molecular dissection of host cell invasion by the Apicomplexans: the glideosome
Gliding motility is an essential and fascinating apicomplexantypical adaptation to an intracellular lifestyle. Apicomplexan parasites rely on gliding motility for their migration across biological barriers and for host cell invasion and egress. This unusual substrate-dependent mode of locomotion inv...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2008-09-01
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| Series: | Parasite |
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| Online Access: | http://dx.doi.org/10.1051/parasite/2008153197 |
| _version_ | 1827614859671371776 |
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| author | Soldati-Favre D. |
| author_facet | Soldati-Favre D. |
| author_sort | Soldati-Favre D. |
| collection | DOAJ |
| description | Gliding motility is an essential and fascinating apicomplexantypical adaptation to an intracellular lifestyle. Apicomplexan parasites rely on gliding motility for their migration across biological barriers and for host cell invasion and egress. This unusual substrate-dependent mode of locomotion involves the concerted action of secretory adhesins, a myosin motor, factors regulating actin dynamics and proteases. During invasion, complexes of soluble and transmembrane micronemes proteins (MICs) and rhoptry neck proteins (RONs) are discharged to the apical pole of the parasite, some protein acts as adhesins and bind to host cell receptors whereas others are involved in the moving junction formation. These complexes redistribute towards the posterior pole of the parasite via a physical connection to the parasite actomyosin system and are eventually released from the parasite surface by the action of parasite proteases. |
| first_indexed | 2024-03-09T09:01:55Z |
| format | Article |
| id | doaj.art-2c5bb348d3ca49f596eb3f6d93cfbbfb |
| institution | Directory Open Access Journal |
| issn | 1252-607X 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T09:01:55Z |
| publishDate | 2008-09-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-2c5bb348d3ca49f596eb3f6d93cfbbfb2023-12-02T11:27:14ZengEDP SciencesParasite1252-607X1776-10422008-09-0115319720510.1051/parasite/2008153197parasite2008153p197Molecular dissection of host cell invasion by the Apicomplexans: the glideosomeSoldati-Favre D.Gliding motility is an essential and fascinating apicomplexantypical adaptation to an intracellular lifestyle. Apicomplexan parasites rely on gliding motility for their migration across biological barriers and for host cell invasion and egress. This unusual substrate-dependent mode of locomotion involves the concerted action of secretory adhesins, a myosin motor, factors regulating actin dynamics and proteases. During invasion, complexes of soluble and transmembrane micronemes proteins (MICs) and rhoptry neck proteins (RONs) are discharged to the apical pole of the parasite, some protein acts as adhesins and bind to host cell receptors whereas others are involved in the moving junction formation. These complexes redistribute towards the posterior pole of the parasite via a physical connection to the parasite actomyosin system and are eventually released from the parasite surface by the action of parasite proteases.http://dx.doi.org/10.1051/parasite/2008153197Toxoplasma gondiiPlasmodium falciparumApicomplexaadhesinmicronemeactinmyosinproteases |
| spellingShingle | Soldati-Favre D. Molecular dissection of host cell invasion by the Apicomplexans: the glideosome Parasite Toxoplasma gondii Plasmodium falciparum Apicomplexa adhesin microneme actin myosin proteases |
| title | Molecular dissection of host cell invasion by the Apicomplexans: the glideosome |
| title_full | Molecular dissection of host cell invasion by the Apicomplexans: the glideosome |
| title_fullStr | Molecular dissection of host cell invasion by the Apicomplexans: the glideosome |
| title_full_unstemmed | Molecular dissection of host cell invasion by the Apicomplexans: the glideosome |
| title_short | Molecular dissection of host cell invasion by the Apicomplexans: the glideosome |
| title_sort | molecular dissection of host cell invasion by the apicomplexans the glideosome |
| topic | Toxoplasma gondii Plasmodium falciparum Apicomplexa adhesin microneme actin myosin proteases |
| url | http://dx.doi.org/10.1051/parasite/2008153197 |
| work_keys_str_mv | AT soldatifavred moleculardissectionofhostcellinvasionbytheapicomplexanstheglideosome |