Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats
Background & Objective: Addiction to opiates such as morphine is one of major public health problems. It has been shown that in addicted animals, administration of antioxidant agents such as vitamin C can reduce the withdrawal symptoms (WDS). The aim of this study was to evaluate the preventiona...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2008-04-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-283&slc_lang=en&sid=1 |
| _version_ | 1818752687736356864 |
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| author | Alireza Sarkaki Khalil Saadipour Mohammad Kazem Gharib Naseri Mohammad Badavi |
| author_facet | Alireza Sarkaki Khalil Saadipour Mohammad Kazem Gharib Naseri Mohammad Badavi |
| author_sort | Alireza Sarkaki |
| collection | DOAJ |
| description | Background & Objective: Addiction to opiates such as morphine is one of major public health problems. It has been shown that in addicted animals, administration of antioxidant agents such as vitamin C can reduce the withdrawal symptoms (WDS). The aim of this study was to evaluate the preventional effect of grapefruit juice (Citrus Paradisi Macf.) on withdrawal symptoms in rats. Materials & Methods: In this experimental study, Sixteen male Wistar rats (250-300g) randomly divided into two groups (n=8). All animals were addicted by intraperitoneal (i.p) injection of morphine (the 1-3 days: 10 mg/kg, the 4-6 days: 20 mg/kg and the 7-9 days 40 mg/kg daily) for 9 days. The first group received 2 ml Citrus Paradisi Macf. orally 1 hour before morphine administration. The sham group received 2 ml of normal saline. Naloxone (10mg/kg, s.c) was administrated 45 minutes after of an additional dose of morphine (40 mg/kg) in the tenth day for withdrawal symptoms inducing. Then withdrawal symptoms such as frequency of wet-dog shaking, teeth chattering, defecation and penis licking were evaluated for 30 minutes. Results: All withdrawal symptoms including frequency of wet-dog shaking, teeth chattering, defecation and penis licking were reduced in the Citrus Paradisi Macf. group in comparison with the sham group significantly (p<0.05). Conclusion: Our results showed that presumably antioxidant activity of Citrus Paradisi Macf. can reduce withdrawal symptoms. Although the exact mechanisms of its effect in brain need to be elucidate. |
| first_indexed | 2024-12-18T04:55:26Z |
| format | Article |
| id | doaj.art-2c5ccec8fc99464aa876553229f75f90 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-18T04:55:26Z |
| publishDate | 2008-04-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-2c5ccec8fc99464aa876553229f75f902022-12-21T21:20:18ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802008-04-011011620Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male ratsAlireza Sarkaki0Khalil Saadipour1Mohammad Kazem Gharib Naseri2Mohammad Badavi3 Background & Objective: Addiction to opiates such as morphine is one of major public health problems. It has been shown that in addicted animals, administration of antioxidant agents such as vitamin C can reduce the withdrawal symptoms (WDS). The aim of this study was to evaluate the preventional effect of grapefruit juice (Citrus Paradisi Macf.) on withdrawal symptoms in rats. Materials & Methods: In this experimental study, Sixteen male Wistar rats (250-300g) randomly divided into two groups (n=8). All animals were addicted by intraperitoneal (i.p) injection of morphine (the 1-3 days: 10 mg/kg, the 4-6 days: 20 mg/kg and the 7-9 days 40 mg/kg daily) for 9 days. The first group received 2 ml Citrus Paradisi Macf. orally 1 hour before morphine administration. The sham group received 2 ml of normal saline. Naloxone (10mg/kg, s.c) was administrated 45 minutes after of an additional dose of morphine (40 mg/kg) in the tenth day for withdrawal symptoms inducing. Then withdrawal symptoms such as frequency of wet-dog shaking, teeth chattering, defecation and penis licking were evaluated for 30 minutes. Results: All withdrawal symptoms including frequency of wet-dog shaking, teeth chattering, defecation and penis licking were reduced in the Citrus Paradisi Macf. group in comparison with the sham group significantly (p<0.05). Conclusion: Our results showed that presumably antioxidant activity of Citrus Paradisi Macf. can reduce withdrawal symptoms. Although the exact mechanisms of its effect in brain need to be elucidate.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-283&slc_lang=en&sid=1Grapefruit juiceMorphineWithdrawal symptomsRat |
| spellingShingle | Alireza Sarkaki Khalil Saadipour Mohammad Kazem Gharib Naseri Mohammad Badavi Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats مجله دانشگاه علوم پزشکی گرگان Grapefruit juice Morphine Withdrawal symptoms Rat |
| title | Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats |
| title_full | Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats |
| title_fullStr | Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats |
| title_full_unstemmed | Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats |
| title_short | Preventive effect of grapefruit juice (Citrus Paradisi Macf.) on morphine withdrawal symptome in male rats |
| title_sort | preventive effect of grapefruit juice citrus paradisi macf on morphine withdrawal symptome in male rats |
| topic | Grapefruit juice Morphine Withdrawal symptoms Rat |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-283&slc_lang=en&sid=1 |
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