Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
Background: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dil...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.586240/full |
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| author | Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang |
| author_facet | Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang |
| author_sort | Li-fang Ye |
| collection | DOAJ |
| description | Background: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dilated cardiomyopathy and reduced EF in our center and who underwent follow-up examination of EF via echocardiography after 6 months. The EF improved at 6 months in 88 participants, who were included in the heart failure with recovered EF (HFrecEF) subgroup. Patients in whom the EF remained reduced were included in the heart failure with persistently reduced EF (persistent HFrEF) subgroup. Our analyses revealed that EF increase correlated with age (r = −0.254, P = 0.001), left ventricular diastolic dimension (LVDD; r = −0.210, P = 0.004), diabetes (P = 0.034), brain natriuretic peptide (r = −0.199, P = 0.007), and BMI grade (P = 0.000). BMI grade was significantly associated with elevated EF after adjustment for other variables (P = 0.001). On multivariable analysis, compared to patients with persistent HFrEF, those with HFrecEF had higher BMI [odds ratio (OR) = 2.342 per one standard deviation increase; P = 0.001] and lower LVDD (OR = 0.466 per one standard deviation increase; P = 0.001). ROC-curve analysis data showed that BMI > 22.66 kg/m2 (sensitivity 84.1%, specificity 59.4%, AUC 0.745, P = 0.000) indicate high probability of EF recovery in 6 months.Conclusions: Our data suggest that higher BMI is strongly correlated with the recovered EF and that BMI is an effective predictor of EF improvement in patients with heart failure and reduced EF. |
| first_indexed | 2024-12-20T02:57:40Z |
| format | Article |
| id | doaj.art-2c5db270ec5e4e6786512c8846971b66 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-20T02:57:40Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-2c5db270ec5e4e6786512c8846971b662022-12-21T19:55:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-12-01810.3389/fcvm.2021.586240586240Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart FailureLi-fang Ye0Li-fang Ye1Xue-ling Li2Xue-ling Li3Shao-mei Wang4Shao-mei Wang5Yun-fan Wang6Yun-fan Wang7Ya-ru Zheng8Ya-ru Zheng9Li-hong Wang10Li-hong Wang11Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaPeople's Hospital of Hangzhou Medical College, Hangzhou, ChinaBackground: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dilated cardiomyopathy and reduced EF in our center and who underwent follow-up examination of EF via echocardiography after 6 months. The EF improved at 6 months in 88 participants, who were included in the heart failure with recovered EF (HFrecEF) subgroup. Patients in whom the EF remained reduced were included in the heart failure with persistently reduced EF (persistent HFrEF) subgroup. Our analyses revealed that EF increase correlated with age (r = −0.254, P = 0.001), left ventricular diastolic dimension (LVDD; r = −0.210, P = 0.004), diabetes (P = 0.034), brain natriuretic peptide (r = −0.199, P = 0.007), and BMI grade (P = 0.000). BMI grade was significantly associated with elevated EF after adjustment for other variables (P = 0.001). On multivariable analysis, compared to patients with persistent HFrEF, those with HFrecEF had higher BMI [odds ratio (OR) = 2.342 per one standard deviation increase; P = 0.001] and lower LVDD (OR = 0.466 per one standard deviation increase; P = 0.001). ROC-curve analysis data showed that BMI > 22.66 kg/m2 (sensitivity 84.1%, specificity 59.4%, AUC 0.745, P = 0.000) indicate high probability of EF recovery in 6 months.Conclusions: Our data suggest that higher BMI is strongly correlated with the recovered EF and that BMI is an effective predictor of EF improvement in patients with heart failure and reduced EF.https://www.frontiersin.org/articles/10.3389/fcvm.2021.586240/fullbody mass indexobesityleft ventricular ejection fractionimprovementheart failure |
| spellingShingle | Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure Frontiers in Cardiovascular Medicine body mass index obesity left ventricular ejection fraction improvement heart failure |
| title | Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure |
| title_full | Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure |
| title_fullStr | Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure |
| title_full_unstemmed | Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure |
| title_short | Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure |
| title_sort | body mass index an effective predictor of ejection fraction improvement in heart failure |
| topic | body mass index obesity left ventricular ejection fraction improvement heart failure |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.586240/full |
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