Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned
Introduction Megacalycosis is a rare disorder related to congenital underdevelopment of the renal papilla or structural defect of the renal calyces. Megacalycosis has a wide spectrum of clinical presentations ranging from simple variants without any significance on renal function to severe complicat...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12597 |
| _version_ | 1797789266982469632 |
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| author | Andrea Benedetto Galosi Carlotta Nedbal Vanessa Palantrani Andrea Ranghino Roberta Mazzucchelli Carlo Giulioni Giulio Milanese Daniele Castellani |
| author_facet | Andrea Benedetto Galosi Carlotta Nedbal Vanessa Palantrani Andrea Ranghino Roberta Mazzucchelli Carlo Giulioni Giulio Milanese Daniele Castellani |
| author_sort | Andrea Benedetto Galosi |
| collection | DOAJ |
| description | Introduction Megacalycosis is a rare disorder related to congenital underdevelopment of the renal papilla or structural defect of the renal calyces. Megacalycosis has a wide spectrum of clinical presentations ranging from simple variants without any significance on renal function to severe complications. Any prevention strategy is recommended yet since megacalycosis is mostly asymptomatic and usually discovered either accidentally or as result of its complications. Case presentation We observed megacalycosis progression in a young female with a single kidney toward progressive calyx dilatation for years, which ended in acute pyelonephritis. Conservative management, urinary drainage, and large‐spectrum antibiotics were unsuccessful and nephrectomy was required. Conclusion This rare case and literature review add evidence to identify prognostic factors to select patients with a high risk of complications (single kidney, bilateral disease, female gender, associated genetic syndromes, vesicoureteral reflux, and contralateral renal disorder). One o more factors should activate close monitoring and prophylactic therapy if needed. |
| first_indexed | 2024-03-13T01:48:16Z |
| format | Article |
| id | doaj.art-2c5f106fb55f4cb1a703440b11da111d |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-03-13T01:48:16Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-2c5f106fb55f4cb1a703440b11da111d2023-07-03T00:17:01ZengWileyIJU Case Reports2577-171X2023-07-016424424710.1002/iju5.12597Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learnedAndrea Benedetto Galosi0Carlotta Nedbal1Vanessa Palantrani2Andrea Ranghino3Roberta Mazzucchelli4Carlo Giulioni5Giulio Milanese6Daniele Castellani7Department of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyDepartment of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyDepartment of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyNephrology Division Azienda Ospedaliero Universitaria delle Marche Ancona ItalyAnatomic Pathology section Univeristà Politecnica delle Marche Ancona ItalyDepartment of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyDepartment of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyDepartment of Urology Azienda Ospedaliero Universitaria delle Marche, Univeristà Politecnica delle Marche Ancona ItalyIntroduction Megacalycosis is a rare disorder related to congenital underdevelopment of the renal papilla or structural defect of the renal calyces. Megacalycosis has a wide spectrum of clinical presentations ranging from simple variants without any significance on renal function to severe complications. Any prevention strategy is recommended yet since megacalycosis is mostly asymptomatic and usually discovered either accidentally or as result of its complications. Case presentation We observed megacalycosis progression in a young female with a single kidney toward progressive calyx dilatation for years, which ended in acute pyelonephritis. Conservative management, urinary drainage, and large‐spectrum antibiotics were unsuccessful and nephrectomy was required. Conclusion This rare case and literature review add evidence to identify prognostic factors to select patients with a high risk of complications (single kidney, bilateral disease, female gender, associated genetic syndromes, vesicoureteral reflux, and contralateral renal disorder). One o more factors should activate close monitoring and prophylactic therapy if needed.https://doi.org/10.1002/iju5.12597acute pyelonephritisdialysismegacalycosissolitary kidney |
| spellingShingle | Andrea Benedetto Galosi Carlotta Nedbal Vanessa Palantrani Andrea Ranghino Roberta Mazzucchelli Carlo Giulioni Giulio Milanese Daniele Castellani Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned IJU Case Reports acute pyelonephritis dialysis megacalycosis solitary kidney |
| title | Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned |
| title_full | Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned |
| title_fullStr | Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned |
| title_full_unstemmed | Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned |
| title_short | Clinical progression of megacalycosis in a girl with a solitary kidney: The lesson learned |
| title_sort | clinical progression of megacalycosis in a girl with a solitary kidney the lesson learned |
| topic | acute pyelonephritis dialysis megacalycosis solitary kidney |
| url | https://doi.org/10.1002/iju5.12597 |
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