Reawakening GDNF's regenerative past in mice and humans
The ability of an animal to regenerate lost tissue and body parts has obviously life-saving implications. Understanding how this ability became restricted or active in specific animal lineages will help us understand our own regeneration. According to phylogenic analysis, the glial cell line-derived...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235232042200027X |
| _version_ | 1828811869549232128 |
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| author | Andres Samos Vanessa McGaughey Sandra Rieger Thomas S. Lisse |
| author_facet | Andres Samos Vanessa McGaughey Sandra Rieger Thomas S. Lisse |
| author_sort | Andres Samos |
| collection | DOAJ |
| description | The ability of an animal to regenerate lost tissue and body parts has obviously life-saving implications. Understanding how this ability became restricted or active in specific animal lineages will help us understand our own regeneration. According to phylogenic analysis, the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, but not other family members, is conserved in axolotls, a salamander with remarkable regenerative capacity. Furthermore, comparing the pro-regenerative Spiny mouse to its less regenerative descendant, the House mouse, revealed that the GDNF signaling pathway, but not other family members, was induced in regenerating Spiny mice. According to GDNF receptor expression analysis, GDNF may promote hair follicle neogenesis – an important feature of skin regeneration – by determining the fate of dermal fibroblasts as part of new hair follicles. These findings support the idea that GDNF treatment will promote skin regeneration in humans by demonstrating the GDNF signaling pathway's ancestral and cellular nature. |
| first_indexed | 2024-12-12T09:33:46Z |
| format | Article |
| id | doaj.art-2c6215005d904d31aaa097466891cc79 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-12-12T09:33:46Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-2c6215005d904d31aaa097466891cc792022-12-22T00:28:46ZengElsevierRegenerative Therapy2352-32042022-06-01207885Reawakening GDNF's regenerative past in mice and humansAndres Samos0Vanessa McGaughey1Sandra Rieger2Thomas S. Lisse3University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USAUniversity of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USAUniversity of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USAUniversity of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA; Corresponding author. Biology Department, University of Miami, 1308 Memorial Drive, Cox Science Center, Room 229, Coral Gable, FL 33146, USA.The ability of an animal to regenerate lost tissue and body parts has obviously life-saving implications. Understanding how this ability became restricted or active in specific animal lineages will help us understand our own regeneration. According to phylogenic analysis, the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, but not other family members, is conserved in axolotls, a salamander with remarkable regenerative capacity. Furthermore, comparing the pro-regenerative Spiny mouse to its less regenerative descendant, the House mouse, revealed that the GDNF signaling pathway, but not other family members, was induced in regenerating Spiny mice. According to GDNF receptor expression analysis, GDNF may promote hair follicle neogenesis – an important feature of skin regeneration – by determining the fate of dermal fibroblasts as part of new hair follicles. These findings support the idea that GDNF treatment will promote skin regeneration in humans by demonstrating the GDNF signaling pathway's ancestral and cellular nature.http://www.sciencedirect.com/science/article/pii/S235232042200027XHair folliclesWound healingWound repairSkinRegenerationGDNF |
| spellingShingle | Andres Samos Vanessa McGaughey Sandra Rieger Thomas S. Lisse Reawakening GDNF's regenerative past in mice and humans Regenerative Therapy Hair follicles Wound healing Wound repair Skin Regeneration GDNF |
| title | Reawakening GDNF's regenerative past in mice and humans |
| title_full | Reawakening GDNF's regenerative past in mice and humans |
| title_fullStr | Reawakening GDNF's regenerative past in mice and humans |
| title_full_unstemmed | Reawakening GDNF's regenerative past in mice and humans |
| title_short | Reawakening GDNF's regenerative past in mice and humans |
| title_sort | reawakening gdnf s regenerative past in mice and humans |
| topic | Hair follicles Wound healing Wound repair Skin Regeneration GDNF |
| url | http://www.sciencedirect.com/science/article/pii/S235232042200027X |
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