Estradiol decreases blood pressure in association with redox regulation in preeclampsia
In this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10 mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1368538 |
| _version_ | 1797681362113658880 |
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| author | Goran M. Babic Snezana D. Markovic Mirjana Varjacic Natasa Z. Djordjevic Tamara Nikolic Isidora Stojic Vladimir Jakovljevic |
| author_facet | Goran M. Babic Snezana D. Markovic Mirjana Varjacic Natasa Z. Djordjevic Tamara Nikolic Isidora Stojic Vladimir Jakovljevic |
| author_sort | Goran M. Babic |
| collection | DOAJ |
| description | In this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10 mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor induction. The analyses of mean arterial pressure (MAP), serum estradiol concentrations, plasma superoxide anion (O2.), hydrogen peroxide (H2O2), nitrites (NO2−), and peroxynitrite (ONOO−) were conducted before and during the therapy. We found that the plasma concentrations of oxidative stress markers, such as O2– and H2O2, are higher in preeclampsia and positively correlated with the MAP value. Moreover, it was shown that the plasma concentration of NO2– as an indicator of NO levels is higher in preeclampsia. A short-term intramuscular application of estradiol decreases the MAP value and the plasma concentration of O.–, H2O2, NO2−, and ONOO– in preeclampsia. A positive correlation between the decrease of MAP values and the decrease of plasma concentrations of O2–, H2O2, and ONOO– was found in preeclampsia during a short-term estradiol therapy. We conclude that the short-term estradiol therapy decreases the MAP value in preeclampsia by modulating the plasma oxidative stress. We speculate that the estradiol metabolism in preeclampsia is an important mechanism that contributes to vascular dysfunction. |
| first_indexed | 2024-03-11T23:43:47Z |
| format | Article |
| id | doaj.art-2c64a51b7312440f937ab4718550bc99 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:47Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-2c64a51b7312440f937ab4718550bc992023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-04-0140328128610.1080/10641963.2017.13685381368538Estradiol decreases blood pressure in association with redox regulation in preeclampsiaGoran M. Babic0Snezana D. Markovic1Mirjana Varjacic2Natasa Z. Djordjevic3Tamara Nikolic4Isidora Stojic5Vladimir Jakovljevic6University of KragujevacUniversity of KragujevacUniversity of KragujevacState University of Novi PazarUniversity of KragujevacUniversity of KragujevacUniversity of KragujevacIn this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10 mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor induction. The analyses of mean arterial pressure (MAP), serum estradiol concentrations, plasma superoxide anion (O2.), hydrogen peroxide (H2O2), nitrites (NO2−), and peroxynitrite (ONOO−) were conducted before and during the therapy. We found that the plasma concentrations of oxidative stress markers, such as O2– and H2O2, are higher in preeclampsia and positively correlated with the MAP value. Moreover, it was shown that the plasma concentration of NO2– as an indicator of NO levels is higher in preeclampsia. A short-term intramuscular application of estradiol decreases the MAP value and the plasma concentration of O.–, H2O2, NO2−, and ONOO– in preeclampsia. A positive correlation between the decrease of MAP values and the decrease of plasma concentrations of O2–, H2O2, and ONOO– was found in preeclampsia during a short-term estradiol therapy. We conclude that the short-term estradiol therapy decreases the MAP value in preeclampsia by modulating the plasma oxidative stress. We speculate that the estradiol metabolism in preeclampsia is an important mechanism that contributes to vascular dysfunction.http://dx.doi.org/10.1080/10641963.2017.1368538estradiolhypertensionoxidative stresspreeclampsiavascular dysfunction |
| spellingShingle | Goran M. Babic Snezana D. Markovic Mirjana Varjacic Natasa Z. Djordjevic Tamara Nikolic Isidora Stojic Vladimir Jakovljevic Estradiol decreases blood pressure in association with redox regulation in preeclampsia Clinical and Experimental Hypertension estradiol hypertension oxidative stress preeclampsia vascular dysfunction |
| title | Estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| title_full | Estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| title_fullStr | Estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| title_full_unstemmed | Estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| title_short | Estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| title_sort | estradiol decreases blood pressure in association with redox regulation in preeclampsia |
| topic | estradiol hypertension oxidative stress preeclampsia vascular dysfunction |
| url | http://dx.doi.org/10.1080/10641963.2017.1368538 |
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