Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study
Introduction: Gestational Diabetes Mellitus (GDM) and persistent hyperglycaemia postpartum is a rising health challenge. Multiple researches have contributed to the understanding of the magnitude of the causal factors involved. One such factor is Vitamin D deficiency though, widely studied exact rol...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13731/44133_F(KM)_CE[Ra1]_KM_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
| _version_ | 1819011308292407296 |
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| author | Harini Rangaraju Shenbaga Lalitha Sankar |
| author_facet | Harini Rangaraju Shenbaga Lalitha Sankar |
| author_sort | Harini Rangaraju |
| collection | DOAJ |
| description | Introduction: Gestational Diabetes Mellitus (GDM) and persistent hyperglycaemia postpartum is a rising health challenge. Multiple researches have contributed to the understanding of the magnitude of the causal factors involved. One such factor is Vitamin D deficiency though, widely studied exact role in development of Diabetes Mellitus (DM) is not investigated.
Aim: To predict the risk of pre-diabetes and DM in GDM patients with Vitamin D deficiency.
Materials and Methods: Hundred pregnant women were recruited-50 study group, 50 control group; based on WHO criteria for GDM diagnosis at 24-28 weeks of gestation. Study parameters in antepartum period were maternal age, Body Mass Index (BMI), Vitamin D, Fasting blood glucose, 2 hour Oral Glucose Tolerance Test (OGTT). Study parameters in postpartum follow-up were fasting blood glucose, postprandial blood glucose, vitamin D. Mann-Whitney U-test and Binary Logistic regression analysis were the statistical tools used to predict the risk.
Results: Antepartum Vitamin D deficiency (<20 ng/mL) showed 2.2 fold significantly increased risk for developing pre-diabetes and DM. High frequency of pre-diabetes (52% of cases) post-delivery (6 weeks) was proved. Maternal age, BMI and OGTT values had direct relationship in predicting risk of DM which was proved with postpartum follow-up.
Conclusion: Vitamin D deficiency has a significant role in development of pre-diabetes and DM in GDM patients. |
| first_indexed | 2024-12-21T01:26:05Z |
| format | Article |
| id | doaj.art-2c662f176867487bbc2e63c82404d0be |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T01:26:05Z |
| publishDate | 2020-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-2c662f176867487bbc2e63c82404d0be2022-12-21T19:20:30ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-05-01145BC17BC2010.7860/JCDR/2020/44133.13731Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational StudyHarini Rangaraju0Shenbaga Lalitha Sankar1Assistant Professor, Department of Clinical Biochemistry, Sankara Nethralaya, Chennai, Tamil Nadu, India.Assistant Professor, Department of Clinical Biochemistry, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.Introduction: Gestational Diabetes Mellitus (GDM) and persistent hyperglycaemia postpartum is a rising health challenge. Multiple researches have contributed to the understanding of the magnitude of the causal factors involved. One such factor is Vitamin D deficiency though, widely studied exact role in development of Diabetes Mellitus (DM) is not investigated. Aim: To predict the risk of pre-diabetes and DM in GDM patients with Vitamin D deficiency. Materials and Methods: Hundred pregnant women were recruited-50 study group, 50 control group; based on WHO criteria for GDM diagnosis at 24-28 weeks of gestation. Study parameters in antepartum period were maternal age, Body Mass Index (BMI), Vitamin D, Fasting blood glucose, 2 hour Oral Glucose Tolerance Test (OGTT). Study parameters in postpartum follow-up were fasting blood glucose, postprandial blood glucose, vitamin D. Mann-Whitney U-test and Binary Logistic regression analysis were the statistical tools used to predict the risk. Results: Antepartum Vitamin D deficiency (<20 ng/mL) showed 2.2 fold significantly increased risk for developing pre-diabetes and DM. High frequency of pre-diabetes (52% of cases) post-delivery (6 weeks) was proved. Maternal age, BMI and OGTT values had direct relationship in predicting risk of DM which was proved with postpartum follow-up. Conclusion: Vitamin D deficiency has a significant role in development of pre-diabetes and DM in GDM patients.https://jcdr.net/articles/PDF/13731/44133_F(KM)_CE[Ra1]_KM_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdfbiomarkerglucose intolerancepre-diabetesrisk predictionvitamin d deficiency |
| spellingShingle | Harini Rangaraju Shenbaga Lalitha Sankar Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study Journal of Clinical and Diagnostic Research biomarker glucose intolerance pre-diabetes risk prediction vitamin d deficiency |
| title | Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study |
| title_full | Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study |
| title_fullStr | Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study |
| title_full_unstemmed | Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study |
| title_short | Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational Study |
| title_sort | vitamin d levels in gestational diabetes mellitus and its influence on future type 2 diabetes mellitus an observational study |
| topic | biomarker glucose intolerance pre-diabetes risk prediction vitamin d deficiency |
| url | https://jcdr.net/articles/PDF/13731/44133_F(KM)_CE[Ra1]_KM_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
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