PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair
Introduction. Hemostatic abnormalities in liver cirrhosis are complex and multifactorial and may predispose to prolonged hemorrhage following invasive procedures. Due to increased perioperative bleeding risks, patients with cirrhosis should undergo elective surgery after making medical preparatio...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2012-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791212782V.pdf |
| _version_ | 1818564634937917440 |
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| author | Vučelić Dragica Golubović Milka Bjelović Miloš |
| author_facet | Vučelić Dragica Golubović Milka Bjelović Miloš |
| author_sort | Vučelić Dragica |
| collection | DOAJ |
| description | Introduction. Hemostatic abnormalities in liver cirrhosis are complex and multifactorial and may predispose to prolonged hemorrhage following invasive procedures. Due to increased perioperative bleeding risks, patients with cirrhosis should undergo elective surgery after making medical preparations. It has been shown that 1-deamino-8-D-arginine vasopressin (DDAVP), desmopressin, can be used as a safe and effective remedy in preventing and treating bleeding in cirrhotics. However, there is still scarce information of adequate test(s) for assessing effects of DDAVP in platelet dysfunction. The use of platelet function analyzer-100 (PFA-100) allows more reliable assessment of impaired primary hemostasis as well as follow-up of hemostatic changes induced by DDAVP effects. Case Outline. In a 49-year-old male with ethylic liver cirrhosis and prolonged bleeding time scheduled for elective left side inguinal hernia repair, we carried out PFA-100 testing to investigate the patient’s platelet functional status. Results were affirmative for the presence of platelet functional problems. By standard coagulation tests the patient was also identified as having secondary hemostasis. Preoperatively, PFA-100 was used to test the patient’s response to a standard dose of DDAVP, which was favorable. The patient was operated after medical preparations with DDAVP and vitamin K. Neither bleeding complications nor side effects of DDAVP were recorded in the perioperative period. Conclusion. The PFA-100 is a simple and reliable test for the assessment of primary hemostasis as well as in monitoring of DDAVP therapy. |
| first_indexed | 2024-12-14T01:31:21Z |
| format | Article |
| id | doaj.art-2c66e270dce84c0497749ee2798c16f5 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-14T01:31:21Z |
| publishDate | 2012-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-2c66e270dce84c0497749ee2798c16f52022-12-21T23:22:01ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792012-01-0114011-1278278510.2298/SARH1212782VPFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repairVučelić DragicaGolubović MilkaBjelović MilošIntroduction. Hemostatic abnormalities in liver cirrhosis are complex and multifactorial and may predispose to prolonged hemorrhage following invasive procedures. Due to increased perioperative bleeding risks, patients with cirrhosis should undergo elective surgery after making medical preparations. It has been shown that 1-deamino-8-D-arginine vasopressin (DDAVP), desmopressin, can be used as a safe and effective remedy in preventing and treating bleeding in cirrhotics. However, there is still scarce information of adequate test(s) for assessing effects of DDAVP in platelet dysfunction. The use of platelet function analyzer-100 (PFA-100) allows more reliable assessment of impaired primary hemostasis as well as follow-up of hemostatic changes induced by DDAVP effects. Case Outline. In a 49-year-old male with ethylic liver cirrhosis and prolonged bleeding time scheduled for elective left side inguinal hernia repair, we carried out PFA-100 testing to investigate the patient’s platelet functional status. Results were affirmative for the presence of platelet functional problems. By standard coagulation tests the patient was also identified as having secondary hemostasis. Preoperatively, PFA-100 was used to test the patient’s response to a standard dose of DDAVP, which was favorable. The patient was operated after medical preparations with DDAVP and vitamin K. Neither bleeding complications nor side effects of DDAVP were recorded in the perioperative period. Conclusion. The PFA-100 is a simple and reliable test for the assessment of primary hemostasis as well as in monitoring of DDAVP therapy.http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791212782V.pdfplatelet dysfunctionliver cirrhosissurgeryPFA-100DDAVP |
| spellingShingle | Vučelić Dragica Golubović Milka Bjelović Miloš PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair Srpski Arhiv za Celokupno Lekarstvo platelet dysfunction liver cirrhosis surgery PFA-100 DDAVP |
| title | PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair |
| title_full | PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair |
| title_fullStr | PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair |
| title_full_unstemmed | PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair |
| title_short | PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair |
| title_sort | pfa 100 test in the detection of platelet dysfunction and monitoring ddavp in a patient with liver cirrhosis undergoing inguinal hernia repair |
| topic | platelet dysfunction liver cirrhosis surgery PFA-100 DDAVP |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2012/0370-81791212782V.pdf |
| work_keys_str_mv | AT vucelicdragica pfa100testinthedetectionofplateletdysfunctionandmonitoringddavpinapatientwithlivercirrhosisundergoinginguinalherniarepair AT golubovicmilka pfa100testinthedetectionofplateletdysfunctionandmonitoringddavpinapatientwithlivercirrhosisundergoinginguinalherniarepair AT bjelovicmilos pfa100testinthedetectionofplateletdysfunctionandmonitoringddavpinapatientwithlivercirrhosisundergoinginguinalherniarepair |