Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus
Background. The purpose of the study was a retrospective comparative analysis of using insulin analogues of the prolonged and ultra-short action and human genetically engineered insulins of middle and short action in children and adolescents with type 1 diabetes mellitus (DM). Materials and methods....
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2017-11-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | http://iej.zaslavsky.com.ua/article/view/119273 |
| _version_ | 1819107231687245824 |
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| author | О.V. Bolshova N.A. Sprinchuk |
| author_facet | О.V. Bolshova N.A. Sprinchuk |
| author_sort | О.V. Bolshova |
| collection | DOAJ |
| description | Background. The purpose of the study was a retrospective comparative analysis of using insulin analogues of the prolonged and ultra-short action and human genetically engineered insulins of middle and short action in children and adolescents with type 1 diabetes mellitus (DM). Materials and methods. The influence of ultra-rapid insulin analog in comparison with human rapid-action insulin on the course of type 1 DM in 100 children and adolescents was studied. It was applied as basal-bolus regimen of insulin therapy. Analysis of parameters which reflect criteria of insulin therapy effectiveness, positive effect of ultra-rapid insulin analog on the course of DM has been performed. Results. Application of ultra-rapid insulin analog before each meal improved parameters of pre- and postprandial glycemia, decreased the range of fluctuations of blood sugar during the day, reduced and maintained HbA1c level without augmentation of frequency and intensity of hypoglycaemia, and also decreased the level of noctural hypoglycaemia. Conclusions. The ultra-rapid insulin analog is the drug of choice for the effective use in insulin pumps. |
| first_indexed | 2024-12-22T02:50:45Z |
| format | Article |
| id | doaj.art-2c67015bb3b644129fa0952563c2552a |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-22T02:50:45Z |
| publishDate | 2017-11-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-2c67015bb3b644129fa0952563c2552a2022-12-21T18:41:24ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272017-11-0113857458010.22141/2224-0721.13.8.2017.119273119273Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitusО.V. Bolshova0N.A. Sprinchuk1State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineState Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineBackground. The purpose of the study was a retrospective comparative analysis of using insulin analogues of the prolonged and ultra-short action and human genetically engineered insulins of middle and short action in children and adolescents with type 1 diabetes mellitus (DM). Materials and methods. The influence of ultra-rapid insulin analog in comparison with human rapid-action insulin on the course of type 1 DM in 100 children and adolescents was studied. It was applied as basal-bolus regimen of insulin therapy. Analysis of parameters which reflect criteria of insulin therapy effectiveness, positive effect of ultra-rapid insulin analog on the course of DM has been performed. Results. Application of ultra-rapid insulin analog before each meal improved parameters of pre- and postprandial glycemia, decreased the range of fluctuations of blood sugar during the day, reduced and maintained HbA1c level without augmentation of frequency and intensity of hypoglycaemia, and also decreased the level of noctural hypoglycaemia. Conclusions. The ultra-rapid insulin analog is the drug of choice for the effective use in insulin pumps.http://iej.zaslavsky.com.ua/article/view/119273type 1 diabetes mellituschildren and adolescentsbasal-bolus regimen of insulin therapyultra-rapid insulin analogglycemic controlinsulin pump |
| spellingShingle | О.V. Bolshova N.A. Sprinchuk Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus Mìžnarodnij Endokrinologìčnij Žurnal type 1 diabetes mellitus children and adolescents basal-bolus regimen of insulin therapy ultra-rapid insulin analog glycemic control insulin pump |
| title | Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| title_full | Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| title_fullStr | Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| title_full_unstemmed | Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| title_short | Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| title_sort | using ultra rapid insulin analogs in children and adolescents with type 1 diabetes mellitus |
| topic | type 1 diabetes mellitus children and adolescents basal-bolus regimen of insulin therapy ultra-rapid insulin analog glycemic control insulin pump |
| url | http://iej.zaslavsky.com.ua/article/view/119273 |
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