Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging.
PURPOSE:To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). METHODS:Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photome...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6168135?pdf=render |
| _version_ | 1819047058319867904 |
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| author | Siqing Yu Beatrice E Frueh Dagmar Steinmair Andreas Ebneter Sebastian Wolf Martin S Zinkernagel Marion R Munk |
| author_facet | Siqing Yu Beatrice E Frueh Dagmar Steinmair Andreas Ebneter Sebastian Wolf Martin S Zinkernagel Marion R Munk |
| author_sort | Siqing Yu |
| collection | DOAJ |
| description | PURPOSE:To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). METHODS:Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. RESULTS:Thirteen eyes of 12 patients met the inclusion criteria. There was a significant increase of perfusion and vessel densities in both the SCP and the DCP after cataract surgery within the 3 × 3 mm images. Significantly better distinguishability of FAZ border was observed postoperatively in both SCP and DCP, however, FAZ area and perimeter measurements did not significantly change after cataract surgery. Mean number of motion artifacts in SCP and DCP numerically decreased by 37% (P = .089) and 42% (P = .080). CONCLUSIONS:Lens opacities have a significant influence on retinal blood flow measurements in SS-OCTA and should be considered in quantitative vessel analysis. Inflammation may also impact the assessment of density parameters. FAZ measurements seems to be the most robust parameters in terms of media opacity. |
| first_indexed | 2024-12-21T10:54:19Z |
| format | Article |
| id | doaj.art-2c699564e7bf42c5bc679960f3120891 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T10:54:19Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-2c699564e7bf42c5bc679960f31208912022-12-21T19:06:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020450110.1371/journal.pone.0204501Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging.Siqing YuBeatrice E FruehDagmar SteinmairAndreas EbneterSebastian WolfMartin S ZinkernagelMarion R MunkPURPOSE:To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). METHODS:Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. RESULTS:Thirteen eyes of 12 patients met the inclusion criteria. There was a significant increase of perfusion and vessel densities in both the SCP and the DCP after cataract surgery within the 3 × 3 mm images. Significantly better distinguishability of FAZ border was observed postoperatively in both SCP and DCP, however, FAZ area and perimeter measurements did not significantly change after cataract surgery. Mean number of motion artifacts in SCP and DCP numerically decreased by 37% (P = .089) and 42% (P = .080). CONCLUSIONS:Lens opacities have a significant influence on retinal blood flow measurements in SS-OCTA and should be considered in quantitative vessel analysis. Inflammation may also impact the assessment of density parameters. FAZ measurements seems to be the most robust parameters in terms of media opacity.http://europepmc.org/articles/PMC6168135?pdf=render |
| spellingShingle | Siqing Yu Beatrice E Frueh Dagmar Steinmair Andreas Ebneter Sebastian Wolf Martin S Zinkernagel Marion R Munk Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. PLoS ONE |
| title | Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. |
| title_full | Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. |
| title_fullStr | Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. |
| title_full_unstemmed | Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. |
| title_short | Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. |
| title_sort | cataract significantly influences quantitative measurements on swept source optical coherence tomography angiography imaging |
| url | http://europepmc.org/articles/PMC6168135?pdf=render |
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