Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications
Abstract Recently, clustered regularly interspaced palindromic repeats (CRISPR)-Cas9 derived editing tools had significantly improved our ability to make desired changes in the genome. Wild-type Cas9 protein recognizes the target genomic loci and induced local double strand breaks (DSBs) in the guid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2023-04-01
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| Series: | Molecular Biomedicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43556-023-00115-5 |