Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study
Introduction: The supply of selenium (Se) varies widely in Germany. Therefore, a laboratory study was conducted in patients treated at a family doctor practice in Brandenburg, Germany, to determine whether there is a general Se deficiency in this area; specifically, whether Se concentrations differ...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-12-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735418807971 |
| _version_ | 1831625917303095296 |
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| author | Ralph Muecke MD, PhD Knut Waldschock MD Lutz Schomburg PhD Oliver Micke MD, PhD Jens Buentzel MD, PhD Klaus Kisters MD, PhD Irenaeus A. Adamietz MD, PhD Jutta Huebner MD, PhD |
| author_facet | Ralph Muecke MD, PhD Knut Waldschock MD Lutz Schomburg PhD Oliver Micke MD, PhD Jens Buentzel MD, PhD Klaus Kisters MD, PhD Irenaeus A. Adamietz MD, PhD Jutta Huebner MD, PhD |
| author_sort | Ralph Muecke MD, PhD |
| collection | DOAJ |
| description | Introduction: The supply of selenium (Se) varies widely in Germany. Therefore, a laboratory study was conducted in patients treated at a family doctor practice in Brandenburg, Germany, to determine whether there is a general Se deficiency in this area; specifically, whether Se concentrations differ with age, sex, or presence of cancer. Moreover, we tested the effects of a Se supplementation on whole blood Se levels (WBSL). Methods: In 2006, WBSL were analyzed in 871 patients (496 females, 375 males, median age: 67 years). Of these, 143 (78 females, 65 males) had cancer and were in an aftercare situation. From 2006 to 2012, 317 patients (76 with tumors, 241 without tumors) received continuous Se supplementation with sodium selenite (300 µg per day) and annual WBSL measurements. WBSL were compared by Student’s t test for paired and independent samples. Results: The initial WBSL of all patients was 97.2 ± 20.7 µg/L (mean ± SD). WBSL did not differ with regard to age or sex, but patients with cancer had the lowest WBSL. Se supplementation increased mean WBSL in both patients with (to 128.5 µg/L) and without (to 119.52 µg/L) cancer ( P < .001). Discussion: Patients with cancer displayed significantly lower WBSL than patients without cancer, indicating a negative effect of tumors on Se uptake, absorption, or metabolism. Significant influences of age or sex were not observed. Selenite supplementation efficiently improved WBSL to concentrations considered necessary for health benefits. |
| first_indexed | 2024-12-18T23:58:43Z |
| format | Article |
| id | doaj.art-2c6dae807619460ab53a5a69acc88d54 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-18T23:58:43Z |
| publishDate | 2018-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-2c6dae807619460ab53a5a69acc88d542022-12-21T20:46:34ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2018-12-011710.1177/1534735418807971Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory StudyRalph Muecke MD, PhD0Knut Waldschock MD1Lutz Schomburg PhD2Oliver Micke MD, PhD3Jens Buentzel MD, PhD4Klaus Kisters MD, PhD5Irenaeus A. Adamietz MD, PhD6Jutta Huebner MD, PhD7Ruhr University Bochum, Bochum, GermanyFamily Doctor Practice, Golßen, GermanyInstitute for Experimental Endocrinology, Charité, Berlin, GermanyFranziskus Hospital, Bielefeld, GermanySüdharz-Hospital, Nordhausen, GermanySt. Anna Hospital, Herne, GermanyRuhr University Bochum, Bochum, GermanyUniversity Jena, Jena, GermanyIntroduction: The supply of selenium (Se) varies widely in Germany. Therefore, a laboratory study was conducted in patients treated at a family doctor practice in Brandenburg, Germany, to determine whether there is a general Se deficiency in this area; specifically, whether Se concentrations differ with age, sex, or presence of cancer. Moreover, we tested the effects of a Se supplementation on whole blood Se levels (WBSL). Methods: In 2006, WBSL were analyzed in 871 patients (496 females, 375 males, median age: 67 years). Of these, 143 (78 females, 65 males) had cancer and were in an aftercare situation. From 2006 to 2012, 317 patients (76 with tumors, 241 without tumors) received continuous Se supplementation with sodium selenite (300 µg per day) and annual WBSL measurements. WBSL were compared by Student’s t test for paired and independent samples. Results: The initial WBSL of all patients was 97.2 ± 20.7 µg/L (mean ± SD). WBSL did not differ with regard to age or sex, but patients with cancer had the lowest WBSL. Se supplementation increased mean WBSL in both patients with (to 128.5 µg/L) and without (to 119.52 µg/L) cancer ( P < .001). Discussion: Patients with cancer displayed significantly lower WBSL than patients without cancer, indicating a negative effect of tumors on Se uptake, absorption, or metabolism. Significant influences of age or sex were not observed. Selenite supplementation efficiently improved WBSL to concentrations considered necessary for health benefits.https://doi.org/10.1177/1534735418807971 |
| spellingShingle | Ralph Muecke MD, PhD Knut Waldschock MD Lutz Schomburg PhD Oliver Micke MD, PhD Jens Buentzel MD, PhD Klaus Kisters MD, PhD Irenaeus A. Adamietz MD, PhD Jutta Huebner MD, PhD Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study Integrative Cancer Therapies |
| title | Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study |
| title_full | Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study |
| title_fullStr | Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study |
| title_full_unstemmed | Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study |
| title_short | Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study |
| title_sort | whole blood selenium levels and selenium supplementation in patients treated in a family doctor practice in golssen state of brandenburg germany a laboratory study |
| url | https://doi.org/10.1177/1534735418807971 |
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