The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis

The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis

A179L, a non-structural protein of African swine fever virus (ASFV), is capable of suppressing apoptosis by binding the BH3 domain of the pro-apoptotic Bcl-2 family proteins via a conserved ligand binding groove. Our present study aims to determine if A179L affects necroptosis, the second form of pr...

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Bibliographic Details
Main Authors: Jun Shi, Wei Liu, Miao Zhang, Jing Sun, Xiulong Xu
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
African swine fever virus
<i>A179L</i>
apoptosis
necroptosis
Online Access:https://www.mdpi.com/1999-4915/13/12/2490

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