Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs or systems. The etiology of SLE is complex, involving molecular genetics, epigenetics, innate immunity, acquired immunity, race, hormone and environmental factors. Recent progress in fine immunophenotyping, GWAS...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2023-03-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0694 |
| _version_ | 1797851419465744384 |
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| author | SHEN Tian WU Xiaochuan |
| author_facet | SHEN Tian WU Xiaochuan |
| author_sort | SHEN Tian |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs or systems. The etiology of SLE is complex, involving molecular genetics, epigenetics, innate immunity, acquired immunity, race, hormone and environmental factors. Recent progress in fine immunophenotyping, GWAS, single cell sequencing and multiomics analysis has enabled a deeper understanding of the pathogenesis of SLE. Various monoclonal antibodies or small molecule drugs targeting immune cells, costimulatory molecules, cytokines or signal transduction pathways, and CART cell immunotherapy have been developed or even applied in clinical treatment. The approval of belizumab, telitacicept, anifrolumab and voclosporin for SLE has given clinicians, researchers and patients greater confidence and more treatment options for patients with moderate to severe SLE, especially those with refractory SLE. |
| first_indexed | 2024-04-09T19:17:38Z |
| format | Article |
| id | doaj.art-2c6e3005759041419befe74e61ca1daf |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-04-09T19:17:38Z |
| publishDate | 2023-03-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-2c6e3005759041419befe74e61ca1daf2023-04-06T02:09:38ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812023-03-0114223424010.12290/xhyxzz.2022-0694Systemic Lupus Erythematosus: from Pathogenesis to New Targeted TherapiesSHEN TianWU XiaochuanSystemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs or systems. The etiology of SLE is complex, involving molecular genetics, epigenetics, innate immunity, acquired immunity, race, hormone and environmental factors. Recent progress in fine immunophenotyping, GWAS, single cell sequencing and multiomics analysis has enabled a deeper understanding of the pathogenesis of SLE. Various monoclonal antibodies or small molecule drugs targeting immune cells, costimulatory molecules, cytokines or signal transduction pathways, and CART cell immunotherapy have been developed or even applied in clinical treatment. The approval of belizumab, telitacicept, anifrolumab and voclosporin for SLE has given clinicians, researchers and patients greater confidence and more treatment options for patients with moderate to severe SLE, especially those with refractory SLE.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0694systemic lupus erythematosuspathogenesisbiological agentstargeted therapy |
| spellingShingle | SHEN Tian WU Xiaochuan Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies Xiehe Yixue Zazhi systemic lupus erythematosus pathogenesis biological agents targeted therapy |
| title | Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies |
| title_full | Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies |
| title_fullStr | Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies |
| title_full_unstemmed | Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies |
| title_short | Systemic Lupus Erythematosus: from Pathogenesis to New Targeted Therapies |
| title_sort | systemic lupus erythematosus from pathogenesis to new targeted therapies |
| topic | systemic lupus erythematosus pathogenesis biological agents targeted therapy |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0694 |
| work_keys_str_mv | AT shentian systemiclupuserythematosusfrompathogenesistonewtargetedtherapies AT wuxiaochuan systemiclupuserythematosusfrompathogenesistonewtargetedtherapies |