Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential
MicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19–25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species. miRNAs negatively regulate gene expression by binding to the...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Journal of Integrative Agriculture |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095311916615307 |
| _version_ | 1818600525759774720 |
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| author | Xiang-yang MIAO |
| author_facet | Xiang-yang MIAO |
| author_sort | Xiang-yang MIAO |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19–25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species. miRNAs negatively regulate gene expression by binding to the 3′-untranslated regions (3′-UTRs) of their target genes and play an important role in growth, development and the occurrence of diseases. In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs. |
| first_indexed | 2024-12-16T12:36:53Z |
| format | Article |
| id | doaj.art-2c6f7d3e744b4eb0b13d771f56e7958d |
| institution | Directory Open Access Journal |
| issn | 2095-3119 |
| language | English |
| last_indexed | 2024-12-16T12:36:53Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Integrative Agriculture |
| spelling | doaj.art-2c6f7d3e744b4eb0b13d771f56e7958d2022-12-21T22:31:32ZengElsevierJournal of Integrative Agriculture2095-31192017-04-01164753761Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potentialXiang-yang MIAO0Correspondence MIAO Xiang-yang, Tel: +86-10-62895663; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.ChinaMicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19–25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species. miRNAs negatively regulate gene expression by binding to the 3′-untranslated regions (3′-UTRs) of their target genes and play an important role in growth, development and the occurrence of diseases. In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs.http://www.sciencedirect.com/science/article/pii/S2095311916615307miRNAgene expressiongene regulationgene transcriptionexosomesnon-coding RNA |
| spellingShingle | Xiang-yang MIAO Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential Journal of Integrative Agriculture miRNA gene expression gene regulation gene transcription exosomes non-coding RNA |
| title | Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential |
| title_full | Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential |
| title_fullStr | Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential |
| title_full_unstemmed | Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential |
| title_short | Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential |
| title_sort | recent advances in understanding the role of mirnas in exosomes and their therapeutic potential |
| topic | miRNA gene expression gene regulation gene transcription exosomes non-coding RNA |
| url | http://www.sciencedirect.com/science/article/pii/S2095311916615307 |
| work_keys_str_mv | AT xiangyangmiao recentadvancesinunderstandingtheroleofmirnasinexosomesandtheirtherapeuticpotential |