Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

Abstract Background PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICALM is highly expressed in brain endothelium. PICALM endothelial levels are reduced in AD brains. PICALM controls several steps in Aβ transcytosis across the blood-br...

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Bibliographic Details
Main Authors: Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao, Berislav V. Zlokovic
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Neurodegeneration
Subjects:
Artesunate
PICALM
Blood-brain barrier
Alzheimer’s disease
Amyloid-β
Mice
Online Access:https://doi.org/10.1186/s13024-023-00597-5

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