The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
Lung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is...
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| Format: | Article |
| Language: | English |
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University of Belgrade, Medical Faculty
2021-01-01
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| Series: | Medicinski Podmladak |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2021/0369-15272102040S.pdf |
| _version_ | 1818855450243760128 |
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| author | Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila |
| author_facet | Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila |
| author_sort | Spasić Jelena |
| collection | DOAJ |
| description | Lung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is well known and can be a limiting factor in the adequate treatment delivery of the drug. There are important inter-individual differences in the efficacy and the toxicity of all chemotherapy drugs, which cannot be explained solely by the characteristics of the tumor. In order to define predictive factors for the occurrence of toxic effects, numerous genetic alterations have been investigated - especially single nucleotide polymorphisms (SNPs). The investigated genes are those involved in DNA repair mechanisms, signal pathways of apoptosis, DNA synthesis, transport mechanisms, but often with inconclusive and opposing results. It is clear that the effect of SNPs on the occurrence of cisplatin toxicity cannot be explained by investigating just one or several genes alone, but epigenetic interactions must be investigated, as well as interactions with outside factors. The study of SNPs is, however, a relatively simple and inexpensive method and, as such, can be used as one of the prognostic tools for everyday practice. |
| first_indexed | 2024-12-19T08:08:48Z |
| format | Article |
| id | doaj.art-2c714b8dd9444eafb3e3c08582c8394a |
| institution | Directory Open Access Journal |
| issn | 0369-1527 2466-5525 |
| language | English |
| last_indexed | 2024-12-19T08:08:48Z |
| publishDate | 2021-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj.art-2c714b8dd9444eafb3e3c08582c8394a2022-12-21T20:29:41ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252021-01-01722404710.5937/mp72-319400369-15272102040SThe influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancerSpasić Jelena0https://orcid.org/0000-0002-1386-9114Radosavljević Davorin1Nagorni-Obradović Ljudmila2https://orcid.org/0000-0001-9413-5683Institut za onkologiju i radiologiju Srbije, Beograd, SerbiaInstitut za onkologiju i radiologiju Srbije, Beograd, SerbiaUKCS, Univerzitet u Beogradu, Medicinski fakultet, Klinika za pulmologiju, Beograd, SerbiaLung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is well known and can be a limiting factor in the adequate treatment delivery of the drug. There are important inter-individual differences in the efficacy and the toxicity of all chemotherapy drugs, which cannot be explained solely by the characteristics of the tumor. In order to define predictive factors for the occurrence of toxic effects, numerous genetic alterations have been investigated - especially single nucleotide polymorphisms (SNPs). The investigated genes are those involved in DNA repair mechanisms, signal pathways of apoptosis, DNA synthesis, transport mechanisms, but often with inconclusive and opposing results. It is clear that the effect of SNPs on the occurrence of cisplatin toxicity cannot be explained by investigating just one or several genes alone, but epigenetic interactions must be investigated, as well as interactions with outside factors. The study of SNPs is, however, a relatively simple and inexpensive method and, as such, can be used as one of the prognostic tools for everyday practice.https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2021/0369-15272102040S.pdfsingle nucleotide polymorphismscisplatintoxicity |
| spellingShingle | Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer Medicinski Podmladak single nucleotide polymorphisms cisplatin toxicity |
| title | The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer |
| title_full | The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer |
| title_fullStr | The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer |
| title_full_unstemmed | The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer |
| title_short | The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer |
| title_sort | influence of genetic polymorphisms on the toxicity of platinum based chemotherapy in the treatment of non small cell lung cancer |
| topic | single nucleotide polymorphisms cisplatin toxicity |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2021/0369-15272102040S.pdf |
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