High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients
Most patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunit A (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progress...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.563666/full |
| _version_ | 1818404726311485440 |
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| author | Yifeng Sun Zhao Xu Jifeng Jiang Tianhong Xu Jiadai Xu Peng Liu |
| author_facet | Yifeng Sun Zhao Xu Jifeng Jiang Tianhong Xu Jiadai Xu Peng Liu |
| author_sort | Yifeng Sun |
| collection | DOAJ |
| description | Most patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunit A (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progression-free survival. Furthermore, SDHA high expression inhibited proliferation and invasion in MM cell lines and enhanced the anti-tumor and synergistic effect of chemotherapeutics. More importantly, chidamide was proved effective in MM by targeting SDHA, and expression of SDHA was increased by chidamide through acetylating H3K27 site of SDHA. Collectively, high expression of SDHA, which was regulated by histone acetylation and targeted by chidamide, might become a good prognostic factor of MM patients. |
| first_indexed | 2024-12-14T08:44:44Z |
| format | Article |
| id | doaj.art-2c756fa040c14a1c8c4a10b66b72830d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T08:44:44Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2c756fa040c14a1c8c4a10b66b72830d2022-12-21T23:09:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.563666563666High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma PatientsYifeng SunZhao XuJifeng JiangTianhong XuJiadai XuPeng LiuMost patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunit A (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progression-free survival. Furthermore, SDHA high expression inhibited proliferation and invasion in MM cell lines and enhanced the anti-tumor and synergistic effect of chemotherapeutics. More importantly, chidamide was proved effective in MM by targeting SDHA, and expression of SDHA was increased by chidamide through acetylating H3K27 site of SDHA. Collectively, high expression of SDHA, which was regulated by histone acetylation and targeted by chidamide, might become a good prognostic factor of MM patients.https://www.frontiersin.org/article/10.3389/fonc.2020.563666/fullmultiple myelomasuccinate dehydrogenase subunit Aproliferation and invasionsynergistic effecthistone acetylation |
| spellingShingle | Yifeng Sun Zhao Xu Jifeng Jiang Tianhong Xu Jiadai Xu Peng Liu High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients Frontiers in Oncology multiple myeloma succinate dehydrogenase subunit A proliferation and invasion synergistic effect histone acetylation |
| title | High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients |
| title_full | High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients |
| title_fullStr | High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients |
| title_full_unstemmed | High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients |
| title_short | High Expression of Succinate Dehydrogenase Subunit A Which Is Regulated by Histone Acetylation, Acts as a Good Prognostic Factor of Multiple Myeloma Patients |
| title_sort | high expression of succinate dehydrogenase subunit a which is regulated by histone acetylation acts as a good prognostic factor of multiple myeloma patients |
| topic | multiple myeloma succinate dehydrogenase subunit A proliferation and invasion synergistic effect histone acetylation |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.563666/full |
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