Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers
As variable after effects have been observed following phasic muscle contraction prior to continuous theta-burst stimulation (cTBS), we here investigated two cTBS protocols (cTBS300 and cTBS600) in 20 healthy participants employing a pre-relaxed muscle condition including visual feedback on idle per...
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/6/737 |
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| author | Jan Haeckert John Rothwell Ricci Hannah Alkomiet Hasan Wolfgang Strube |
| author_facet | Jan Haeckert John Rothwell Ricci Hannah Alkomiet Hasan Wolfgang Strube |
| author_sort | Jan Haeckert |
| collection | DOAJ |
| description | As variable after effects have been observed following phasic muscle contraction prior to continuous theta-burst stimulation (cTBS), we here investigated two cTBS protocols (cTBS300 and cTBS600) in 20 healthy participants employing a pre-relaxed muscle condition including visual feedback on idle peripheral surface EMG activity. Furthermore, we assessed corticospinal excitability measures also from a pre-relaxed state to better understand the potential impact of these proposed contributors to TBS. Motor-evoked potential (MEP) magnitude changes were assessed for 30 min. The linear model computed across both experimental paradigms (cTBS300 and cTBS600) revealed a main effect of TIME COURSE (<i>p</i> = 0.044). Separate exploratory analysis for cTBS300 revealed a main effect of TIME COURSE (<i>p</i> = 0.031), which did not maintain significance after Greenhouse–Geisser correction (<i>p</i> = 0.073). For cTBS600, no main effects were observed. An exploratory analysis revealed a correlation between relative SICF at 2.0 ms (<i>p</i> = 0.006) and after effects (relative mean change) of cTBS600, which did not survive correction for multiple testing. Our findings thereby do not support the hypothesis of a specific excitability modulating effect of cTBS applied to the human motor-cortex in setups with pre-relaxed muscle conditions. |
| first_indexed | 2024-03-10T10:48:34Z |
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| id | doaj.art-2c759bf2137048568ea1b47d60e63365 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T10:48:34Z |
| publishDate | 2021-06-01 |
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| spelling | doaj.art-2c759bf2137048568ea1b47d60e633652023-11-21T22:24:23ZengMDPI AGBrain Sciences2076-34252021-06-0111673710.3390/brainsci11060737Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy VolunteersJan Haeckert0John Rothwell1Ricci Hannah2Alkomiet Hasan3Wolfgang Strube4Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, BKH Augsburg, Dr.-Mack-Str. 1, 86156 Augsburg, GermanySobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UKDepartment of Psychology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USADepartment of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, BKH Augsburg, Dr.-Mack-Str. 1, 86156 Augsburg, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, BKH Augsburg, Dr.-Mack-Str. 1, 86156 Augsburg, GermanyAs variable after effects have been observed following phasic muscle contraction prior to continuous theta-burst stimulation (cTBS), we here investigated two cTBS protocols (cTBS300 and cTBS600) in 20 healthy participants employing a pre-relaxed muscle condition including visual feedback on idle peripheral surface EMG activity. Furthermore, we assessed corticospinal excitability measures also from a pre-relaxed state to better understand the potential impact of these proposed contributors to TBS. Motor-evoked potential (MEP) magnitude changes were assessed for 30 min. The linear model computed across both experimental paradigms (cTBS300 and cTBS600) revealed a main effect of TIME COURSE (<i>p</i> = 0.044). Separate exploratory analysis for cTBS300 revealed a main effect of TIME COURSE (<i>p</i> = 0.031), which did not maintain significance after Greenhouse–Geisser correction (<i>p</i> = 0.073). For cTBS600, no main effects were observed. An exploratory analysis revealed a correlation between relative SICF at 2.0 ms (<i>p</i> = 0.006) and after effects (relative mean change) of cTBS600, which did not survive correction for multiple testing. Our findings thereby do not support the hypothesis of a specific excitability modulating effect of cTBS applied to the human motor-cortex in setups with pre-relaxed muscle conditions.https://www.mdpi.com/2076-3425/11/6/737non-invasive brain stimulationcontinuous theta burst stimulation (cTBS)cTBS 300 versus cTBS 600pre-relaxed muscle conditionhealthy participants |
| spellingShingle | Jan Haeckert John Rothwell Ricci Hannah Alkomiet Hasan Wolfgang Strube Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers Brain Sciences non-invasive brain stimulation continuous theta burst stimulation (cTBS) cTBS 300 versus cTBS 600 pre-relaxed muscle condition healthy participants |
| title | Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers |
| title_full | Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers |
| title_fullStr | Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers |
| title_full_unstemmed | Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers |
| title_short | Comparative Study of a Continuous Train of Theta-Burst Stimulation for a Duration of 20 s (cTBS 300) versus a Duration of 40 s (cTBS 600) in a Pre-Stimulation Relaxed Condition in Healthy Volunteers |
| title_sort | comparative study of a continuous train of theta burst stimulation for a duration of 20 s ctbs 300 versus a duration of 40 s ctbs 600 in a pre stimulation relaxed condition in healthy volunteers |
| topic | non-invasive brain stimulation continuous theta burst stimulation (cTBS) cTBS 300 versus cTBS 600 pre-relaxed muscle condition healthy participants |
| url | https://www.mdpi.com/2076-3425/11/6/737 |
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