Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients

<p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of singl...

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Main Authors: Li Jie-Hui, Ma Guo-Guo, Zhu Shu-Qiang, Yan Hao, Wu Yong-Bing, Xu Jian-Jun
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Online Access:http://www.cardiothoracicsurgery.org/content/7/1/97
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author Li Jie-Hui
Ma Guo-Guo
Zhu Shu-Qiang
Yan Hao
Wu Yong-Bing
Xu Jian-Jun
author_facet Li Jie-Hui
Ma Guo-Guo
Zhu Shu-Qiang
Yan Hao
Wu Yong-Bing
Xu Jian-Jun
author_sort Li Jie-Hui
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of single nucleotide polymorphisms (SNPs) affecting vitamin K or warfarin metabolism have been shown to affect warfarin dosing. Our aim was to study the effect of the CYP4F2 rs2108622-1347 (C > T) variant on warfarin dosing in Chinese patients.</p> <p>Methods</p> <p>We studied 352 patients after heart valve replacement surgery. Warfarin dosing for patients was adjusted to achieve 1.8 ≤ INR ≤ 2.5. We determined the presence of SNPs in CYP4F2 in these patients and investigated their association with warfarin dosing.</p> <p>Results</p> <p>We found the frequency of the CYP4F2 rs2108622 C allele was 79.5% and T-allele frequency was 20.5%. The warfarin dose requirement for CC individuals was significantly lower than that for CT or TT individuals (<it>P</it> < 0.05). TT-homozygous individuals required a 0.56 mg/day higher dose of warfarin than their CC counterparts.</p> <p>Conclusions</p> <p>This study demonstrates that CYP4F2 rs2108622 significantly affects the warfarin dose requirement to achieve adequate anticoagulant activity in Chinese individuals. Genotyping of this SNP may allow clinicians to determine the initiation dose for patients following valve-replacement surgery in China.</p>
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spelling doaj.art-2c77756300574beca71f595631d696cc2022-12-22T01:01:49ZengBMCJournal of Cardiothoracic Surgery1749-80902012-09-01719710.1186/1749-8090-7-97Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patientsLi Jie-HuiMa Guo-GuoZhu Shu-QiangYan HaoWu Yong-BingXu Jian-Jun<p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of single nucleotide polymorphisms (SNPs) affecting vitamin K or warfarin metabolism have been shown to affect warfarin dosing. Our aim was to study the effect of the CYP4F2 rs2108622-1347 (C > T) variant on warfarin dosing in Chinese patients.</p> <p>Methods</p> <p>We studied 352 patients after heart valve replacement surgery. Warfarin dosing for patients was adjusted to achieve 1.8 ≤ INR ≤ 2.5. We determined the presence of SNPs in CYP4F2 in these patients and investigated their association with warfarin dosing.</p> <p>Results</p> <p>We found the frequency of the CYP4F2 rs2108622 C allele was 79.5% and T-allele frequency was 20.5%. The warfarin dose requirement for CC individuals was significantly lower than that for CT or TT individuals (<it>P</it> < 0.05). TT-homozygous individuals required a 0.56 mg/day higher dose of warfarin than their CC counterparts.</p> <p>Conclusions</p> <p>This study demonstrates that CYP4F2 rs2108622 significantly affects the warfarin dose requirement to achieve adequate anticoagulant activity in Chinese individuals. Genotyping of this SNP may allow clinicians to determine the initiation dose for patients following valve-replacement surgery in China.</p>http://www.cardiothoracicsurgery.org/content/7/1/97WarfarinCYP4F2SNPValveImplantINR
spellingShingle Li Jie-Hui
Ma Guo-Guo
Zhu Shu-Qiang
Yan Hao
Wu Yong-Bing
Xu Jian-Jun
Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
Journal of Cardiothoracic Surgery
Warfarin
CYP4F2
SNP
Valve
Implant
INR
title Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
title_full Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
title_fullStr Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
title_full_unstemmed Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
title_short Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
title_sort correlation between single nucleotide polymorphisms in cyp4f2 and warfarin dosing in chinese valve replacement patients
topic Warfarin
CYP4F2
SNP
Valve
Implant
INR
url http://www.cardiothoracicsurgery.org/content/7/1/97
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