Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients
<p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of singl...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-09-01
|
Series: | Journal of Cardiothoracic Surgery |
Subjects: | |
Online Access: | http://www.cardiothoracicsurgery.org/content/7/1/97 |
_version_ | 1818155457440645120 |
---|---|
author | Li Jie-Hui Ma Guo-Guo Zhu Shu-Qiang Yan Hao Wu Yong-Bing Xu Jian-Jun |
author_facet | Li Jie-Hui Ma Guo-Guo Zhu Shu-Qiang Yan Hao Wu Yong-Bing Xu Jian-Jun |
author_sort | Li Jie-Hui |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of single nucleotide polymorphisms (SNPs) affecting vitamin K or warfarin metabolism have been shown to affect warfarin dosing. Our aim was to study the effect of the CYP4F2 rs2108622-1347 (C > T) variant on warfarin dosing in Chinese patients.</p> <p>Methods</p> <p>We studied 352 patients after heart valve replacement surgery. Warfarin dosing for patients was adjusted to achieve 1.8 ≤ INR ≤ 2.5. We determined the presence of SNPs in CYP4F2 in these patients and investigated their association with warfarin dosing.</p> <p>Results</p> <p>We found the frequency of the CYP4F2 rs2108622 C allele was 79.5% and T-allele frequency was 20.5%. The warfarin dose requirement for CC individuals was significantly lower than that for CT or TT individuals (<it>P</it> < 0.05). TT-homozygous individuals required a 0.56 mg/day higher dose of warfarin than their CC counterparts.</p> <p>Conclusions</p> <p>This study demonstrates that CYP4F2 rs2108622 significantly affects the warfarin dose requirement to achieve adequate anticoagulant activity in Chinese individuals. Genotyping of this SNP may allow clinicians to determine the initiation dose for patients following valve-replacement surgery in China.</p> |
first_indexed | 2024-12-11T14:42:42Z |
format | Article |
id | doaj.art-2c77756300574beca71f595631d696cc |
institution | Directory Open Access Journal |
issn | 1749-8090 |
language | English |
last_indexed | 2024-12-11T14:42:42Z |
publishDate | 2012-09-01 |
publisher | BMC |
record_format | Article |
series | Journal of Cardiothoracic Surgery |
spelling | doaj.art-2c77756300574beca71f595631d696cc2022-12-22T01:01:49ZengBMCJournal of Cardiothoracic Surgery1749-80902012-09-01719710.1186/1749-8090-7-97Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patientsLi Jie-HuiMa Guo-GuoZhu Shu-QiangYan HaoWu Yong-BingXu Jian-Jun<p>Abstract</p> <p>Background</p> <p>Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy with warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number of single nucleotide polymorphisms (SNPs) affecting vitamin K or warfarin metabolism have been shown to affect warfarin dosing. Our aim was to study the effect of the CYP4F2 rs2108622-1347 (C > T) variant on warfarin dosing in Chinese patients.</p> <p>Methods</p> <p>We studied 352 patients after heart valve replacement surgery. Warfarin dosing for patients was adjusted to achieve 1.8 ≤ INR ≤ 2.5. We determined the presence of SNPs in CYP4F2 in these patients and investigated their association with warfarin dosing.</p> <p>Results</p> <p>We found the frequency of the CYP4F2 rs2108622 C allele was 79.5% and T-allele frequency was 20.5%. The warfarin dose requirement for CC individuals was significantly lower than that for CT or TT individuals (<it>P</it> < 0.05). TT-homozygous individuals required a 0.56 mg/day higher dose of warfarin than their CC counterparts.</p> <p>Conclusions</p> <p>This study demonstrates that CYP4F2 rs2108622 significantly affects the warfarin dose requirement to achieve adequate anticoagulant activity in Chinese individuals. Genotyping of this SNP may allow clinicians to determine the initiation dose for patients following valve-replacement surgery in China.</p>http://www.cardiothoracicsurgery.org/content/7/1/97WarfarinCYP4F2SNPValveImplantINR |
spellingShingle | Li Jie-Hui Ma Guo-Guo Zhu Shu-Qiang Yan Hao Wu Yong-Bing Xu Jian-Jun Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients Journal of Cardiothoracic Surgery Warfarin CYP4F2 SNP Valve Implant INR |
title | Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients |
title_full | Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients |
title_fullStr | Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients |
title_full_unstemmed | Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients |
title_short | Correlation between single nucleotide polymorphisms in CYP4F2 and warfarin dosing in chinese valve replacement patients |
title_sort | correlation between single nucleotide polymorphisms in cyp4f2 and warfarin dosing in chinese valve replacement patients |
topic | Warfarin CYP4F2 SNP Valve Implant INR |
url | http://www.cardiothoracicsurgery.org/content/7/1/97 |
work_keys_str_mv | AT lijiehui correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients AT maguoguo correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients AT zhushuqiang correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients AT yanhao correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients AT wuyongbing correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients AT xujianjun correlationbetweensinglenucleotidepolymorphismsincyp4f2andwarfarindosinginchinesevalvereplacementpatients |