Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort
Abstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associa...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-020-00679-7 |
| _version_ | 1818322805652979712 |
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| author | Hong Liang Ziliang Wang Maohua Miao Youping Tian Yan Zhou Sheng Wen Yao Chen Xiaowei Sun Wei Yuan |
| author_facet | Hong Liang Ziliang Wang Maohua Miao Youping Tian Yan Zhou Sheng Wen Yao Chen Xiaowei Sun Wei Yuan |
| author_sort | Hong Liang |
| collection | DOAJ |
| description | Abstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones. |
| first_indexed | 2024-12-13T11:02:38Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-13T11:02:38Z |
| publishDate | 2020-11-01 |
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| series | Environmental Health |
| spelling | doaj.art-2c7893ddc37143b9a0ce8ed6480a26d22022-12-21T23:49:13ZengBMCEnvironmental Health1476-069X2020-11-0119111410.1186/s12940-020-00679-7Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohortHong Liang0Ziliang Wang1Maohua Miao2Youping Tian3Yan Zhou4Sheng Wen5Yao Chen6Xiaowei Sun7Wei Yuan8Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityNational Management Office of Neonatal Screening Project for CHD, Children’s Hospital of Fudan UniversityNational Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and PreventionNational Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and PreventionDepartment of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityDepartment of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan UniversityAbstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones.http://link.springer.com/article/10.1186/s12940-020-00679-7Perfluoroalkyl substancesPrenatal exposureThyroid hormonesCord bloodBayesian kernel machine regressionProspective cohort study |
| spellingShingle | Hong Liang Ziliang Wang Maohua Miao Youping Tian Yan Zhou Sheng Wen Yao Chen Xiaowei Sun Wei Yuan Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort Environmental Health Perfluoroalkyl substances Prenatal exposure Thyroid hormones Cord blood Bayesian kernel machine regression Prospective cohort study |
| title | Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort |
| title_full | Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort |
| title_fullStr | Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort |
| title_full_unstemmed | Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort |
| title_short | Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort |
| title_sort | prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a chinese birth cohort |
| topic | Perfluoroalkyl substances Prenatal exposure Thyroid hormones Cord blood Bayesian kernel machine regression Prospective cohort study |
| url | http://link.springer.com/article/10.1186/s12940-020-00679-7 |
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