Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice
We previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration of CTS (1.0 g/kg, for 3 days) decreased the immob...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861317300026 |
| _version_ | 1818837449185427456 |
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| author | Sachie Sasaki-Hamada Azusa Suzuki Yudai Ueda Kinzo Matsumoto Jun-Ichiro Oka |
| author_facet | Sachie Sasaki-Hamada Azusa Suzuki Yudai Ueda Kinzo Matsumoto Jun-Ichiro Oka |
| author_sort | Sachie Sasaki-Hamada |
| collection | DOAJ |
| description | We previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration of CTS (1.0 g/kg, for 3 days) decreased the immobility time in the forced-swim test, and this decrease was prevented by the prior administration of sulpiride (an antagonist of D2/3 receptors) and WAY100635 (an antagonist of 5-HT1A receptors). None of the treatments tested altered the locomotor activity of mice. These results suggest that CTS exerts antidepressant-like effects through changes in the serotonergic and dopaminergic systems. |
| first_indexed | 2024-12-19T03:22:40Z |
| format | Article |
| id | doaj.art-2c7c94047af148d580cbb178294ac4ba |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-19T03:22:40Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-2c7c94047af148d580cbb178294ac4ba2022-12-21T20:37:44ZengElsevierJournal of Pharmacological Sciences1347-86132017-02-01133211011310.1016/j.jphs.2017.01.002Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in miceSachie Sasaki-Hamada0Azusa Suzuki1Yudai Ueda2Kinzo Matsumoto3Jun-Ichiro Oka4Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, JapanDivision of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, JapanWe previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration of CTS (1.0 g/kg, for 3 days) decreased the immobility time in the forced-swim test, and this decrease was prevented by the prior administration of sulpiride (an antagonist of D2/3 receptors) and WAY100635 (an antagonist of 5-HT1A receptors). None of the treatments tested altered the locomotor activity of mice. These results suggest that CTS exerts antidepressant-like effects through changes in the serotonergic and dopaminergic systems.http://www.sciencedirect.com/science/article/pii/S1347861317300026ChotosanAntidepressantsMonoamine |
| spellingShingle | Sachie Sasaki-Hamada Azusa Suzuki Yudai Ueda Kinzo Matsumoto Jun-Ichiro Oka Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice Journal of Pharmacological Sciences Chotosan Antidepressants Monoamine |
| title | Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice |
| title_full | Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice |
| title_fullStr | Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice |
| title_full_unstemmed | Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice |
| title_short | Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice |
| title_sort | serotonergic and dopaminergic systems are implicated in antidepressant like effects of chotosan a kampo formula in mice |
| topic | Chotosan Antidepressants Monoamine |
| url | http://www.sciencedirect.com/science/article/pii/S1347861317300026 |
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