Capturing hammerhead ribozyme structures in action by modulating general base catalysis.

Capturing hammerhead ribozyme structures in action by modulating general base catalysis.

We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modul...

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Bibliographic Details
Main Authors: Young-In Chi, Monika Martick, Monica Lares, Rosalind Kim, William G Scott, Sung-Hou Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2553840?pdf=render

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