Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer
Integrin subunit alpha 3 (ITGA3) expression correlates with the development and prognosis of human cancers. This study aimed to investigate the association of ITGA3 expression with pancreatic cancer (PCa) prognosis. The ITGA3 gene expression data were extracted from The Cancer Genome Atlas (TCGA) pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-12-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2022-0606 |
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| author | Hu Fangfang Zhao Liangtao Wang Yang Ye Hao Tang Haodong Zhou Jiahua |
| author_facet | Hu Fangfang Zhao Liangtao Wang Yang Ye Hao Tang Haodong Zhou Jiahua |
| author_sort | Hu Fangfang |
| collection | DOAJ |
| description | Integrin subunit alpha 3 (ITGA3) expression correlates with the development and prognosis of human cancers. This study aimed to investigate the association of ITGA3 expression with pancreatic cancer (PCa) prognosis. The ITGA3 gene expression data were extracted from The Cancer Genome Atlas (TCGA) pancreatic adenocarcinoma (PAAD) cohort and 14 Gene Expression Omnibus microarray datasets. The differences in ITGA3 expression levels between tumor and non-tumor tissues were compared using the Mann–Whitney U test. Cox regression analysis and meta-analysis were performed to detect the association of ITGA3 expression with PCa prognosis. ITGA3 expression was higher in tumors than in controls. Tumors with advanced grades (3/4) had higher ITGA3 levels compared with early-grade tumors (1/2). The meta-analysis of the TCGA PAAD cohort and seven microarray datasets (GSE28735, GSE62452, GSE79668, GSE71729, GSE57495, GSE78229, and GSE21501) showed that ITGA3 was a prognostic biomarker in PCa (hazard ratio (HR) = 1.38, 95% confidence interval (CI) 1.26–1.51, p < 0.00001). Five ITGA3-related genes, including ITGB1 (HR = 1.6), ITGB5 (HR = 1.6), ITGB6 (HR = 1.6), LAMA3 (HR = 2.1), and CD9 (HR = 2.3), correlated with PCa prognosis significantly (p < 0.05). Functional enrichment analysis showed that ITGA3 was related to “hsa04151: PI3K-Akt signaling pathway” and “hsa04510: Focal adhesion.” We concluded that high ITGA3 expression was a potential prognostic biomarker in PCa. |
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| id | doaj.art-2c80818f29d647aaac21e62a53de6210 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-10T21:32:25Z |
| publishDate | 2022-12-01 |
| publisher | De Gruyter |
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| series | Open Medicine |
| spelling | doaj.art-2c80818f29d647aaac21e62a53de62102023-01-19T13:04:57ZengDe GruyterOpen Medicine2391-54632022-12-011711935194310.1515/med-2022-0606Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancerHu Fangfang0Zhao Liangtao1Wang Yang2Ye Hao3Tang Haodong4Zhou Jiahua5Department of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, 210009, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, 210009, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, 210009, ChinaSchool of Medicine, Southeast University, Nanjing, 210009, ChinaSchool of Medicine, Southeast University, Nanjing, 210009, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhongda Hospital Affiliated to Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, 210009, ChinaIntegrin subunit alpha 3 (ITGA3) expression correlates with the development and prognosis of human cancers. This study aimed to investigate the association of ITGA3 expression with pancreatic cancer (PCa) prognosis. The ITGA3 gene expression data were extracted from The Cancer Genome Atlas (TCGA) pancreatic adenocarcinoma (PAAD) cohort and 14 Gene Expression Omnibus microarray datasets. The differences in ITGA3 expression levels between tumor and non-tumor tissues were compared using the Mann–Whitney U test. Cox regression analysis and meta-analysis were performed to detect the association of ITGA3 expression with PCa prognosis. ITGA3 expression was higher in tumors than in controls. Tumors with advanced grades (3/4) had higher ITGA3 levels compared with early-grade tumors (1/2). The meta-analysis of the TCGA PAAD cohort and seven microarray datasets (GSE28735, GSE62452, GSE79668, GSE71729, GSE57495, GSE78229, and GSE21501) showed that ITGA3 was a prognostic biomarker in PCa (hazard ratio (HR) = 1.38, 95% confidence interval (CI) 1.26–1.51, p < 0.00001). Five ITGA3-related genes, including ITGB1 (HR = 1.6), ITGB5 (HR = 1.6), ITGB6 (HR = 1.6), LAMA3 (HR = 2.1), and CD9 (HR = 2.3), correlated with PCa prognosis significantly (p < 0.05). Functional enrichment analysis showed that ITGA3 was related to “hsa04151: PI3K-Akt signaling pathway” and “hsa04510: Focal adhesion.” We concluded that high ITGA3 expression was a potential prognostic biomarker in PCa.https://doi.org/10.1515/med-2022-0606pancreatic cancerintegrin alpha 3meta-analysispi3k-akt signaling pathwayextracellular matrix |
| spellingShingle | Hu Fangfang Zhao Liangtao Wang Yang Ye Hao Tang Haodong Zhou Jiahua Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer Open Medicine pancreatic cancer integrin alpha 3 meta-analysis pi3k-akt signaling pathway extracellular matrix |
| title | Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| title_full | Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| title_fullStr | Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| title_full_unstemmed | Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| title_short | Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| title_sort | integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer |
| topic | pancreatic cancer integrin alpha 3 meta-analysis pi3k-akt signaling pathway extracellular matrix |
| url | https://doi.org/10.1515/med-2022-0606 |
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