P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES?
Background: In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, as compared to subjects matched for age and sex. Aim of this study was to anal...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2015-11-01
|
| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930644/view |
| _version_ | 1828748197263048704 |
|---|---|
| author | A. Paini* L. Andreoli M. Salvetti F. Dall’Ara S. Piantoni C. Donini C. Agabiti Rosei F. Bertacchini D. Stassaldi E. Agabiti Rosei A. Tincani M.L. Muiesan |
| author_facet | A. Paini* L. Andreoli M. Salvetti F. Dall’Ara S. Piantoni C. Donini C. Agabiti Rosei F. Bertacchini D. Stassaldi E. Agabiti Rosei A. Tincani M.L. Muiesan |
| author_sort | A. Paini* |
| collection | DOAJ |
| description | Background: In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, as compared to subjects matched for age and sex.
Aim of this study was to analyze the presence of target organ damage in premenopausal women with SLE and in controls matched not only for demographic characteristics but also for other cardiovascular risk factors.
Subjects and methods: 4 patients with SLE clinically stable(SLEDAI Score 2.5±1.5)(age 32±7years, range 19-44)and 34 controls matched for sex, age, BMI, clinic blood pressure(BP) and antihypertensive treatment(if present), underwent:24 hours BP monitoring, echocardiography with tissue Doppler analysis(TDI) for the evaluation of left ventricular(LV)structure and of systolic and diastolic function, carotid ultrasound for intima-media thickness(IMT), carotid distensibility measurement, and pulse wave velocity measurement(PWV).
Results: By definition no difference was observed for age, sex, BMI and clinic BP values and a similar Framingham risk score was observed between SLE and controls(1.3±2.7 vs 1.5±2.3%, p=ns). No significant differences were observed for all echocardiographic parameters except LV longitudinal systolic function(Sm), an early index of LV systolic dysfunction(see Table). Carotid IMT and distensibility, as well as PWV and the prevalence of an abnormal aortic stiffness were both similar in the two groups. At the logistic analysis, PWV was independently associated with LV mass in controls and with the steroid weekly dose in SLE patients.
Conclusions: In patients with SLE and low activity index of the disease we did not observe significant vascular alterations as compare to controls with similar cardiovascular risk. The early LV systolic impairment observed in this group of patients needs confirmation in larger cohorts. |
| first_indexed | 2024-04-14T04:56:43Z |
| format | Article |
| id | doaj.art-2c81a47e35a740cf929fc1e51429c098 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-14T04:56:43Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-2c81a47e35a740cf929fc1e51429c0982022-12-22T02:11:07ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.302P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES?A. Paini*L. AndreoliM. SalvettiF. Dall’AraS. PiantoniC. DoniniC. Agabiti RoseiF. BertacchiniD. StassaldiE. Agabiti RoseiA. TincaniM.L. MuiesanBackground: In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, as compared to subjects matched for age and sex. Aim of this study was to analyze the presence of target organ damage in premenopausal women with SLE and in controls matched not only for demographic characteristics but also for other cardiovascular risk factors. Subjects and methods: 4 patients with SLE clinically stable(SLEDAI Score 2.5±1.5)(age 32±7years, range 19-44)and 34 controls matched for sex, age, BMI, clinic blood pressure(BP) and antihypertensive treatment(if present), underwent:24 hours BP monitoring, echocardiography with tissue Doppler analysis(TDI) for the evaluation of left ventricular(LV)structure and of systolic and diastolic function, carotid ultrasound for intima-media thickness(IMT), carotid distensibility measurement, and pulse wave velocity measurement(PWV). Results: By definition no difference was observed for age, sex, BMI and clinic BP values and a similar Framingham risk score was observed between SLE and controls(1.3±2.7 vs 1.5±2.3%, p=ns). No significant differences were observed for all echocardiographic parameters except LV longitudinal systolic function(Sm), an early index of LV systolic dysfunction(see Table). Carotid IMT and distensibility, as well as PWV and the prevalence of an abnormal aortic stiffness were both similar in the two groups. At the logistic analysis, PWV was independently associated with LV mass in controls and with the steroid weekly dose in SLE patients. Conclusions: In patients with SLE and low activity index of the disease we did not observe significant vascular alterations as compare to controls with similar cardiovascular risk. The early LV systolic impairment observed in this group of patients needs confirmation in larger cohorts.https://www.atlantis-press.com/article/125930644/view |
| spellingShingle | A. Paini* L. Andreoli M. Salvetti F. Dall’Ara S. Piantoni C. Donini C. Agabiti Rosei F. Bertacchini D. Stassaldi E. Agabiti Rosei A. Tincani M.L. Muiesan P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? Artery Research |
| title | P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? |
| title_full | P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? |
| title_fullStr | P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? |
| title_full_unstemmed | P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? |
| title_short | P6.18 CARDIOVASCULAR TARGET ORGAN DAMAGE IN PREMENOPAUSAL SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AND IN CONTROLS; ARE THERE ANY DIFFERENCES? |
| title_sort | p6 18 cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls are there any differences |
| url | https://www.atlantis-press.com/article/125930644/view |
| work_keys_str_mv | AT apaini p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT landreoli p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT msalvetti p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT fdallara p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT spiantoni p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT cdonini p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT cagabitirosei p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT fbertacchini p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT dstassaldi p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT eagabitirosei p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT atincani p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences AT mlmuiesan p618cardiovasculartargetorgandamageinpremenopausalsystemiclupuserythematosuspatientsandincontrolsarethereanydifferences |