Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes

Lung cancer is the leading cause of cancer death in the world today, and adenocarcinoma is the most common histopathological type of lung cancer. In May 2021, World Health Organization (WHO) released the 5th edition of the WHO classification of thoracic tumors, which classifies invasive non-mucinous...

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Main Authors: Ruke TANG, Lina BI, Bingquan XIANG, Lianhua YE, Ying CHEN, Guangjian LI, Guangqiang ZHAO, Yunchao HUANG
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2023-01-01
Series:Chinese Journal of Lung Cancer
Subjects:
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.51
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author Ruke TANG
Lina BI
Bingquan XIANG
Lianhua YE
Ying CHEN
Guangjian LI
Guangqiang ZHAO
Yunchao HUANG
author_facet Ruke TANG
Lina BI
Bingquan XIANG
Lianhua YE
Ying CHEN
Guangjian LI
Guangqiang ZHAO
Yunchao HUANG
author_sort Ruke TANG
collection DOAJ
description Lung cancer is the leading cause of cancer death in the world today, and adenocarcinoma is the most common histopathological type of lung cancer. In May 2021, World Health Organization (WHO) released the 5th edition of the WHO classification of thoracic tumors, which classifies invasive non-mucinous adenocarcinoma (INMA) into lepidic adenocarcinoma, acinar adenocarcinoma, papillary adenocarcinoma, solid adenocarcinoma, and micropapillary adenocarcinoma based on its histological characteristics. These five pathological subtypes differ in clinical features, treatment and prognosis. A complete understanding of the characteristics of these subtypes is essential for the clinical diagnosis, treatment options, and prognosis predictions of patients with lung adenocarcinoma, including recurrence and progression. This article will review the grading system, morphology, imaging prediction, lymph node metastasis, surgery, chemotherapy, targeted therapy and immunotherapy of different pathological subtypes of INMA.
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spelling doaj.art-2c83a19f38744db0b423b8cd838244232023-02-16T00:55:34ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-01-01261223010.3779/j.issn.1009-3419.2022.102.51Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological SubtypesRuke TANG0Lina BI1Bingquan XIANG2Lianhua YE3Ying CHEN4Guangjian LI5Guangqiang ZHAO6Yunchao HUANG7Department of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Nephrology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, ChinaDepartment of Intensive Care Unit, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaDepartment of Thoracic Surgery I, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, ChinaLung cancer is the leading cause of cancer death in the world today, and adenocarcinoma is the most common histopathological type of lung cancer. In May 2021, World Health Organization (WHO) released the 5th edition of the WHO classification of thoracic tumors, which classifies invasive non-mucinous adenocarcinoma (INMA) into lepidic adenocarcinoma, acinar adenocarcinoma, papillary adenocarcinoma, solid adenocarcinoma, and micropapillary adenocarcinoma based on its histological characteristics. These five pathological subtypes differ in clinical features, treatment and prognosis. A complete understanding of the characteristics of these subtypes is essential for the clinical diagnosis, treatment options, and prognosis predictions of patients with lung adenocarcinoma, including recurrence and progression. This article will review the grading system, morphology, imaging prediction, lymph node metastasis, surgery, chemotherapy, targeted therapy and immunotherapy of different pathological subtypes of INMA.http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.51lung neoplasmsinvasive adenocarcinomainvasive non-mucinous adenocarcinomapathological subtypes
spellingShingle Ruke TANG
Lina BI
Bingquan XIANG
Lianhua YE
Ying CHEN
Guangjian LI
Guangqiang ZHAO
Yunchao HUANG
Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
Chinese Journal of Lung Cancer
lung neoplasms
invasive adenocarcinoma
invasive non-mucinous adenocarcinoma
pathological subtypes
title Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
title_full Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
title_fullStr Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
title_full_unstemmed Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
title_short Advances in the Study of Invasive Non-mucinous Adenocarcinoma 
with Different Pathological Subtypes
title_sort advances in the study of invasive non mucinous adenocarcinoma 
with different pathological subtypes
topic lung neoplasms
invasive adenocarcinoma
invasive non-mucinous adenocarcinoma
pathological subtypes
url http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.51
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