Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid
Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation in cancer therapy due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polyme...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2021-09-01
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| Series: | Advanced Pharmaceutical Bulletin |
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| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-11-765.pdf |
| _version_ | 1819349660053012480 |
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| author | Andang Miatmoko |
| author_facet | Andang Miatmoko |
| author_sort | Andang Miatmoko |
| collection | DOAJ |
| description | Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation in cancer therapy due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1. Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5%-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles 10 times higher than cisplatin solution, thus producing high tumor accumulation. Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors. |
| first_indexed | 2024-12-24T19:04:03Z |
| format | Article |
| id | doaj.art-2c84bf2f42e743d7af36139992ef7b49 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-24T19:04:03Z |
| publishDate | 2021-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-2c84bf2f42e743d7af36139992ef7b492022-12-21T16:43:08ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082021-09-0111476577110.34172/apb.2021.086apb-29003Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic AcidAndang Miatmoko0Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C Mulyorejo, Surabaya, 60115, Indonesia.Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation in cancer therapy due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1. Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5%-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles 10 times higher than cisplatin solution, thus producing high tumor accumulation. Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors.https://apb.tbzmed.ac.ir/PDF/apb-11-765.pdfcisplatincanceregg phosphatifylcholinehybrid nanoparticlespolyethylene oxide-b-polymethacrylic acidsurfactants |
| spellingShingle | Andang Miatmoko Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid Advanced Pharmaceutical Bulletin cisplatin cancer egg phosphatifylcholine hybrid nanoparticles polyethylene oxide-b-polymethacrylic acid surfactants |
| title | Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid |
| title_full | Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid |
| title_fullStr | Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid |
| title_full_unstemmed | Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid |
| title_short | Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid |
| title_sort | physical characterization and biodistribution of cisplatin loaded in surfactant modified hybrid nanoparticles using polyethylene oxide b polymethacrylic acid |
| topic | cisplatin cancer egg phosphatifylcholine hybrid nanoparticles polyethylene oxide-b-polymethacrylic acid surfactants |
| url | https://apb.tbzmed.ac.ir/PDF/apb-11-765.pdf |
| work_keys_str_mv | AT andangmiatmoko physicalcharacterizationandbiodistributionofcisplatinloadedinsurfactantmodifiedhybridnanoparticlesusingpolyethyleneoxidebpolymethacrylicacid |