Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6
Hepatocellular carcinoma (HCC), a primary liver cancer, is closely associated with the gut microbiota. However, the role of gut fungi in the development of HCC remains unclear. The aim of this study was to explore the influence of intestinal Candida albicans on HCC. Here, We found that patients with...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.812771/full |
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| author | Zherui Liu Zherui Liu Yinyin Li Chen Li Guanglin Lei Lin Zhou Xiangling Chen Xiaodong Jia Yinying Lu Yinying Lu |
| author_facet | Zherui Liu Zherui Liu Yinyin Li Chen Li Guanglin Lei Lin Zhou Xiangling Chen Xiaodong Jia Yinying Lu Yinying Lu |
| author_sort | Zherui Liu |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC), a primary liver cancer, is closely associated with the gut microbiota. However, the role of gut fungi in the development of HCC remains unclear. The aim of this study was to explore the influence of intestinal Candida albicans on HCC. Here, We found that patients with HCC showed significantly decreased diversity of the gut mycobiome and increased abundance of C. albicans, compared to the patients with liver cirrhosis. The gavage of C. albicans in the WT models increased the tumor size and weight and influenced the plasma metabolome, which was indicated by alterations in 117 metabolites, such as L-carnitine and L-acetylcarnitine, and several KEGG enriched pathways, such as phenylalanine metabolism and citrate cycle. Moreover, the expression of nucleotide oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6) in the intestinal tissues and primary intestinal epithelial cells of the WT mice interacted with C. albicans increased. Notably, the colonization of C. albicans had no effect on tumor growth in Nlrp6–/– mice. In conclusion, the abnormal colonization of C. albicans reprogrammed HCC metabolism and contributed to the progression of HCC dependent on NLRP6, which provided new targets for the treatment of HCC. |
| first_indexed | 2024-12-22T06:39:59Z |
| format | Article |
| id | doaj.art-2c84e76371ec43f79bf8f44d4e24bb86 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T06:39:59Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-2c84e76371ec43f79bf8f44d4e24bb862022-12-21T18:35:27ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-03-011310.3389/fmicb.2022.812771812771Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6Zherui Liu0Zherui Liu1Yinyin Li2Chen Li3Guanglin Lei4Lin Zhou5Xiangling Chen6Xiaodong Jia7Yinying Lu8Yinying Lu9Peking University 302 Clinical Medical School, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Oncology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSenior Department of Oncology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaPeking University 302 Clinical Medical School, Beijing, ChinaSenior Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaHepatocellular carcinoma (HCC), a primary liver cancer, is closely associated with the gut microbiota. However, the role of gut fungi in the development of HCC remains unclear. The aim of this study was to explore the influence of intestinal Candida albicans on HCC. Here, We found that patients with HCC showed significantly decreased diversity of the gut mycobiome and increased abundance of C. albicans, compared to the patients with liver cirrhosis. The gavage of C. albicans in the WT models increased the tumor size and weight and influenced the plasma metabolome, which was indicated by alterations in 117 metabolites, such as L-carnitine and L-acetylcarnitine, and several KEGG enriched pathways, such as phenylalanine metabolism and citrate cycle. Moreover, the expression of nucleotide oligomerization domain-like receptor family pyrin domain containing 6 (NLRP6) in the intestinal tissues and primary intestinal epithelial cells of the WT mice interacted with C. albicans increased. Notably, the colonization of C. albicans had no effect on tumor growth in Nlrp6–/– mice. In conclusion, the abnormal colonization of C. albicans reprogrammed HCC metabolism and contributed to the progression of HCC dependent on NLRP6, which provided new targets for the treatment of HCC.https://www.frontiersin.org/articles/10.3389/fmicb.2022.812771/fullCandida albicansITShepatocellular carcinomametabolomeNLRP6 |
| spellingShingle | Zherui Liu Zherui Liu Yinyin Li Chen Li Guanglin Lei Lin Zhou Xiangling Chen Xiaodong Jia Yinying Lu Yinying Lu Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 Frontiers in Microbiology Candida albicans ITS hepatocellular carcinoma metabolome NLRP6 |
| title | Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 |
| title_full | Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 |
| title_fullStr | Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 |
| title_full_unstemmed | Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 |
| title_short | Intestinal Candida albicans Promotes Hepatocarcinogenesis by Up-Regulating NLRP6 |
| title_sort | intestinal candida albicans promotes hepatocarcinogenesis by up regulating nlrp6 |
| topic | Candida albicans ITS hepatocellular carcinoma metabolome NLRP6 |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.812771/full |
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