Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review
Bacteria and its by-products are found to be the main cause of pulpal and periapical infection of tooth. Infected root canals of tooth harbours a wide variation of microbial flora that includes both Gram-positive and Gram-negative microorganisms. Bacterial components such as Lipopolysaccharide (LPS)...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2021-06-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/gram-positive-bacterial-lipoteichoic-acid-role-in-a-root-canal-infection-a-literature-review/ |
| _version_ | 1819137904698458112 |
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| author | Vinoo Subramaniam Ramachandran Mensudar Rathakrishnan Malathy Balaraman Ravindrran Alargarsamy Venkatesh Vidhya Shankari Shanmugasundaram Karpagavinayagam Kumaraguru |
| author_facet | Vinoo Subramaniam Ramachandran Mensudar Rathakrishnan Malathy Balaraman Ravindrran Alargarsamy Venkatesh Vidhya Shankari Shanmugasundaram Karpagavinayagam Kumaraguru |
| author_sort | Vinoo Subramaniam Ramachandran |
| collection | DOAJ |
| description | Bacteria and its by-products are found to be the main cause of pulpal and periapical infection of tooth. Infected root canals of tooth harbours a wide variation of microbial flora that includes both Gram-positive and Gram-negative microorganisms. Bacterial components such as Lipopolysaccharide (LPS) of gram negative bacteria and Lipoteichoic Acid (LTA) of gram positive bacteria have the potential to enter the peri-apical tissue of tooth and initiate the inflammatory process. After microbial death that occurs either due to body’s defence cells or by antibiotic action , bacterial cell wall components such as LTA are released which can persist inside macrophages for prolonged periods causing chronic inflammation. Once these cell-wall components are recognized by the body immune surveillance cells, numerous inflammatory mediators are released leading to inflammation and subsequent pathological consequences. The purpose of this review is intend to summarize the role of gram positive bacterial component LTA in causing endodontic infection and use of potential therapeutic agents against LTA. |
| first_indexed | 2024-12-22T10:58:17Z |
| format | Article |
| id | doaj.art-2c8633e4348544808e9d9de80948e708 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-22T10:58:17Z |
| publishDate | 2021-06-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-2c8633e4348544808e9d9de80948e7082022-12-21T18:28:33ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2021-06-0115253454310.22207/JPAM.15.2.29Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature ReviewVinoo Subramaniam Ramachandranhttps://orcid.org/0000-0003-3302-5661 Mensudar Rathakrishnanhttps://orcid.org/0000-0003-1758-1975Malathy Balaraman Ravindrranhttps://orcid.org/0000-0002-2534-1587Alargarsamy Venkateshhttps://orcid.org/0000-0002-2243-6003Vidhya Shankari Shanmugasundaramhttps://orcid.org/0000-0003-4125-5635Karpagavinayagam Kumaraguruhttps://orcid.org/0000-0001-6381-1845Bacteria and its by-products are found to be the main cause of pulpal and periapical infection of tooth. Infected root canals of tooth harbours a wide variation of microbial flora that includes both Gram-positive and Gram-negative microorganisms. Bacterial components such as Lipopolysaccharide (LPS) of gram negative bacteria and Lipoteichoic Acid (LTA) of gram positive bacteria have the potential to enter the peri-apical tissue of tooth and initiate the inflammatory process. After microbial death that occurs either due to body’s defence cells or by antibiotic action , bacterial cell wall components such as LTA are released which can persist inside macrophages for prolonged periods causing chronic inflammation. Once these cell-wall components are recognized by the body immune surveillance cells, numerous inflammatory mediators are released leading to inflammation and subsequent pathological consequences. The purpose of this review is intend to summarize the role of gram positive bacterial component LTA in causing endodontic infection and use of potential therapeutic agents against LTA.https://microbiologyjournal.org/gram-positive-bacterial-lipoteichoic-acid-role-in-a-root-canal-infection-a-literature-review/lipoteichoic acid (lta)endodontic infectionenterococcus faecalis lipoteichoic acid |
| spellingShingle | Vinoo Subramaniam Ramachandran Mensudar Rathakrishnan Malathy Balaraman Ravindrran Alargarsamy Venkatesh Vidhya Shankari Shanmugasundaram Karpagavinayagam Kumaraguru Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review Journal of Pure and Applied Microbiology lipoteichoic acid (lta) endodontic infection enterococcus faecalis lipoteichoic acid |
| title | Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review |
| title_full | Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review |
| title_fullStr | Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review |
| title_full_unstemmed | Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review |
| title_short | Gram Positive Bacterial Lipoteichoic Acid Role in a Root Canal Infection – A Literature Review |
| title_sort | gram positive bacterial lipoteichoic acid role in a root canal infection a literature review |
| topic | lipoteichoic acid (lta) endodontic infection enterococcus faecalis lipoteichoic acid |
| url | https://microbiologyjournal.org/gram-positive-bacterial-lipoteichoic-acid-role-in-a-root-canal-infection-a-literature-review/ |
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