Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor

Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor

The SH2 domain-containing adaptor protein ShcA is a proto-oncogene involved in growth factor receptor signaling. The role of phosphorylated ShcA is to link receptor tyrosine kinases with the SH2-containing adaptor protein Grb2, thus facilitating signal transduction from receptor tyrosine kinases to...

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Bibliographic Details
Main Authors: Serenella Eppenberger-Castori, Urs Eppenberger, Willy Küng, Jonas Cicenas
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Cancers
Subjects:
ShcA
immunoassay
kinase
biomarker
estrogen receptor
phosphorylation
breast cancer
Online Access:http://www.mdpi.com/2072-6694/2/1/153/

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