Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits
Sensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse onto spinal cord dorsal horn neurons. Primary afferent central terminals express a wide variety of receptors that modulate glutamate and peptide release. Regulation of the amount and timing of neurotransmitter...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/1/414 |
| _version_ | 1797542520895307776 |
|---|---|
| author | Antonella Comitato Rita Bardoni |
| author_facet | Antonella Comitato Rita Bardoni |
| author_sort | Antonella Comitato |
| collection | DOAJ |
| description | Sensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse onto spinal cord dorsal horn neurons. Primary afferent central terminals express a wide variety of receptors that modulate glutamate and peptide release. Regulation of the amount and timing of neurotransmitter release critically affects the integration of postsynaptic responses and the coding of sensory information. The role of GABA (γ-aminobutyric acid) receptors expressed on afferent central terminals is particularly important in sensory processing, both in physiological conditions and in sensitized states induced by chronic pain. During the last decade, techniques of opto- and chemogenetic stimulation and neuronal selective labeling have provided interesting insights on this topic. This review focused on the recent advances about the modulatory effects of presynaptic GABAergic receptors in spinal cord dorsal horn and the neural circuits involved in these mechanisms. |
| first_indexed | 2024-03-10T13:31:44Z |
| format | Article |
| id | doaj.art-2c880d92efca409abd7a79fdb9d0fa27 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:31:44Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2c880d92efca409abd7a79fdb9d0fa272023-11-21T07:52:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122141410.3390/ijms22010414Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to CircuitsAntonella Comitato0Rita Bardoni1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalySensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse onto spinal cord dorsal horn neurons. Primary afferent central terminals express a wide variety of receptors that modulate glutamate and peptide release. Regulation of the amount and timing of neurotransmitter release critically affects the integration of postsynaptic responses and the coding of sensory information. The role of GABA (γ-aminobutyric acid) receptors expressed on afferent central terminals is particularly important in sensory processing, both in physiological conditions and in sensitized states induced by chronic pain. During the last decade, techniques of opto- and chemogenetic stimulation and neuronal selective labeling have provided interesting insights on this topic. This review focused on the recent advances about the modulatory effects of presynaptic GABAergic receptors in spinal cord dorsal horn and the neural circuits involved in these mechanisms.https://www.mdpi.com/1422-0067/22/1/414sensory transmissiondorsal hornpresynaptic inhibitionGABA |
| spellingShingle | Antonella Comitato Rita Bardoni Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits International Journal of Molecular Sciences sensory transmission dorsal horn presynaptic inhibition GABA |
| title | Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits |
| title_full | Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits |
| title_fullStr | Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits |
| title_full_unstemmed | Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits |
| title_short | Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits |
| title_sort | presynaptic inhibition of pain and touch in the spinal cord from receptors to circuits |
| topic | sensory transmission dorsal horn presynaptic inhibition GABA |
| url | https://www.mdpi.com/1422-0067/22/1/414 |
| work_keys_str_mv | AT antonellacomitato presynapticinhibitionofpainandtouchinthespinalcordfromreceptorstocircuits AT ritabardoni presynapticinhibitionofpainandtouchinthespinalcordfromreceptorstocircuits |