Alveolar Regeneration in COVID-19 Patients: A Network Perspective
A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regener...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/20/11279 |
| _version_ | 1797514288116531200 |
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| author | Shishir K. Gupta Mugdha Srivastava Rashmi Minocha Aman Akash Seema Dangwal Thomas Dandekar |
| author_facet | Shishir K. Gupta Mugdha Srivastava Rashmi Minocha Aman Akash Seema Dangwal Thomas Dandekar |
| author_sort | Shishir K. Gupta |
| collection | DOAJ |
| description | A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients. |
| first_indexed | 2024-03-10T06:29:35Z |
| format | Article |
| id | doaj.art-2c881254c7d74071add57df2a4744c6f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:29:35Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2c881254c7d74071add57df2a4744c6f2023-11-22T18:37:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201127910.3390/ijms222011279Alveolar Regeneration in COVID-19 Patients: A Network PerspectiveShishir K. Gupta0Mugdha Srivastava1Rashmi Minocha2Aman Akash3Seema Dangwal4Thomas Dandekar5Functional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, GermanyFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, GermanyDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, GermanyStanford Cardiovascular Institute, Department of Medicine Stanford University School of Medicine, Palo Alto, CA 94305-5101, USAFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, GermanyA viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients.https://www.mdpi.com/1422-0067/22/20/11279COVID-19SARS-CoV-2alveolar regenerationalveolar fibrosissignaling pathwaynetwork biology |
| spellingShingle | Shishir K. Gupta Mugdha Srivastava Rashmi Minocha Aman Akash Seema Dangwal Thomas Dandekar Alveolar Regeneration in COVID-19 Patients: A Network Perspective International Journal of Molecular Sciences COVID-19 SARS-CoV-2 alveolar regeneration alveolar fibrosis signaling pathway network biology |
| title | Alveolar Regeneration in COVID-19 Patients: A Network Perspective |
| title_full | Alveolar Regeneration in COVID-19 Patients: A Network Perspective |
| title_fullStr | Alveolar Regeneration in COVID-19 Patients: A Network Perspective |
| title_full_unstemmed | Alveolar Regeneration in COVID-19 Patients: A Network Perspective |
| title_short | Alveolar Regeneration in COVID-19 Patients: A Network Perspective |
| title_sort | alveolar regeneration in covid 19 patients a network perspective |
| topic | COVID-19 SARS-CoV-2 alveolar regeneration alveolar fibrosis signaling pathway network biology |
| url | https://www.mdpi.com/1422-0067/22/20/11279 |
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