Potential determinants of T helper 2 markers and their distribution in school-aged children
Background: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 bio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893022000892 |
| _version_ | 1797946348762300416 |
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| author | Houman Goudarzi Atsuko Ikeda-Araki Yu Ait Bamai Sachiko Ito Tasuku Inao Isao Yokota Chihiro Miyashita Reiko Kishi Satoshi Konno |
| author_facet | Houman Goudarzi Atsuko Ikeda-Araki Yu Ait Bamai Sachiko Ito Tasuku Inao Isao Yokota Chihiro Miyashita Reiko Kishi Satoshi Konno |
| author_sort | Houman Goudarzi |
| collection | DOAJ |
| description | Background: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort. Methods: We examined the pre- and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n = 180). Results: At age 9–11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels. Conclusions: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children. |
| first_indexed | 2024-04-10T21:09:36Z |
| format | Article |
| id | doaj.art-2c883af41fe64147a6e6d770170d7685 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-10T21:09:36Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-2c883af41fe64147a6e6d770170d76852023-01-21T04:20:22ZengElsevierAllergology International1323-89302023-01-01721100106Potential determinants of T helper 2 markers and their distribution in school-aged childrenHouman Goudarzi0Atsuko Ikeda-Araki1Yu Ait Bamai2Sachiko Ito3Tasuku Inao4Isao Yokota5Chihiro Miyashita6Reiko Kishi7Satoshi Konno8Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Hokkaido University Center for Environmental and Health Sciences, Sapporo, Japan; Corresponding author. Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, 060-8638, Japan.Hokkaido University Center for Environmental and Health Sciences, Sapporo, Japan; Faculty of Health Sciences, Hokkaido University, Sapporo, JapanHokkaido University Center for Environmental and Health Sciences, Sapporo, JapanHokkaido University Center for Environmental and Health Sciences, Sapporo, JapanDepartment of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, JapanHokkaido University Center for Environmental and Health Sciences, Sapporo, JapanHokkaido University Center for Environmental and Health Sciences, Sapporo, JapanDepartment of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, JapanBackground: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort. Methods: We examined the pre- and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n = 180). Results: At age 9–11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels. Conclusions: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.http://www.sciencedirect.com/science/article/pii/S1323893022000892Childhood allergiesPre- and post-natal factorsProspective birth cohortSchool-age childrenT helper 2 biomarkers |
| spellingShingle | Houman Goudarzi Atsuko Ikeda-Araki Yu Ait Bamai Sachiko Ito Tasuku Inao Isao Yokota Chihiro Miyashita Reiko Kishi Satoshi Konno Potential determinants of T helper 2 markers and their distribution in school-aged children Allergology International Childhood allergies Pre- and post-natal factors Prospective birth cohort School-age children T helper 2 biomarkers |
| title | Potential determinants of T helper 2 markers and their distribution in school-aged children |
| title_full | Potential determinants of T helper 2 markers and their distribution in school-aged children |
| title_fullStr | Potential determinants of T helper 2 markers and their distribution in school-aged children |
| title_full_unstemmed | Potential determinants of T helper 2 markers and their distribution in school-aged children |
| title_short | Potential determinants of T helper 2 markers and their distribution in school-aged children |
| title_sort | potential determinants of t helper 2 markers and their distribution in school aged children |
| topic | Childhood allergies Pre- and post-natal factors Prospective birth cohort School-age children T helper 2 biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S1323893022000892 |
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