The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth

The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth

Bromodomains (BD) are epigenetic readers of histone acetylation involved in chromatin remodeling and transcriptional regulation of several genes including protooncogene cellular myelocytomatosis (c-Myc). c-Myc is difficult to target directly by agents due to its disordered alpha helical protein stru...

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Bibliographic Details
Main Authors: Sanjeev Shukla, Carlos Riveros, Mohammed Al-Toubat, Jonathan Chardon-Robles, Teruko Osumi, Samuel Serrano, Adam M. Kase, Joachim L. Petit, Nathalie Meurice, Justyna Gleba, John A. Copland, Jay Chauhan, Steven Fletcher, K. C. Balaji
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
bromodomain inhibitors
MT-1
prostate cancer
patient-derived xenografts
c-Myc
Online Access:https://www.mdpi.com/2072-6694/15/15/3851

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https://www.mdpi.com/2072-6694/15/15/3851

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