CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells

CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells

Abstract The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still lacking. Here, we show that CTCF can be acetylated at lysine 20 (CTCF-K20) by CREB-binding protein (...

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Bibliographic Details
Main Authors: Shixin Gong, Gongcheng Hu, Rong Guo, Jie Zhang, Yiqi Yang, Binrui Ji, Gang Li, Hongjie Yao
Format: Article
Language:English
Published: SpringerOpen 2022-09-01
Series:Cell Regeneration
Subjects:
CTCF
CTCF acetylation
CBP
HDAC6
Early cardiac mesoderm differentiation
Online Access:https://doi.org/10.1186/s13619-022-00131-w

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