Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations
Cold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damag...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Transplantology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-3943/4/3/13 |
| _version_ | 1797576464721248256 |
|---|---|
| author | Corey Mealer Haley Konsek Zachary Travis Rebecca N. Suk Taufiek Konrad Rajab |
| author_facet | Corey Mealer Haley Konsek Zachary Travis Rebecca N. Suk Taufiek Konrad Rajab |
| author_sort | Corey Mealer |
| collection | DOAJ |
| description | Cold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damage from ischemia and the build-up of waste products and signals that drive reperfusion injury prior to transplantation into a matching recipient. Preventing damage from CIT and WIT and extending the amount of time that organs can tolerate has been a major goal of organ transplantation since donors and recipients are frequently not located within the same hospital, region, or state. Meanwhile, the amount of CIT that a transplant center is willing to accept differs based on the organ, the institution receiving the organ offer, and the doctor receiving the offer for that institution. With the introduction of a partial heart transplantation conducted last year at Duke University, it is important to discuss how much CIT transplant centers conducting a partial heart transplantation (pHT) are willing to accept. This article will review the physiology of WIT and CIT, associated organ damage, CIT variation among transplant centers and organ types, and provide a brief discussion of the future of pHT-accepted CIT and the need for research in this field. |
| first_indexed | 2024-03-10T21:53:23Z |
| format | Article |
| id | doaj.art-2c8b75ff6d5c4a48b05a2593344383a3 |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-10T21:53:23Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-2c8b75ff6d5c4a48b05a2593344383a32023-11-19T13:16:27ZengMDPI AGTransplantology2673-39432023-07-014312413810.3390/transplantology4030013Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart TransplantationsCorey Mealer0Haley Konsek1Zachary Travis2Rebecca N. Suk3Taufiek Konrad Rajab4Department of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USADivision of Research, Alabama College of Osteopathic Medicine, 445 Health Sciences Boulevard, Dothan, AL 36303, USASection of Pediatric Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USACold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damage from ischemia and the build-up of waste products and signals that drive reperfusion injury prior to transplantation into a matching recipient. Preventing damage from CIT and WIT and extending the amount of time that organs can tolerate has been a major goal of organ transplantation since donors and recipients are frequently not located within the same hospital, region, or state. Meanwhile, the amount of CIT that a transplant center is willing to accept differs based on the organ, the institution receiving the organ offer, and the doctor receiving the offer for that institution. With the introduction of a partial heart transplantation conducted last year at Duke University, it is important to discuss how much CIT transplant centers conducting a partial heart transplantation (pHT) are willing to accept. This article will review the physiology of WIT and CIT, associated organ damage, CIT variation among transplant centers and organ types, and provide a brief discussion of the future of pHT-accepted CIT and the need for research in this field.https://www.mdpi.com/2673-3943/4/3/13partial heart transplantischemia and reperfusion injuryheart valvescongenital heart diseasevalve replacementcold preservation |
| spellingShingle | Corey Mealer Haley Konsek Zachary Travis Rebecca N. Suk Taufiek Konrad Rajab Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations Transplantology partial heart transplant ischemia and reperfusion injury heart valves congenital heart disease valve replacement cold preservation |
| title | Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations |
| title_full | Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations |
| title_fullStr | Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations |
| title_full_unstemmed | Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations |
| title_short | Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations |
| title_sort | mechanisms of cold preservation and reperfusion injury for solid organ transplantation implications for partial heart transplantations |
| topic | partial heart transplant ischemia and reperfusion injury heart valves congenital heart disease valve replacement cold preservation |
| url | https://www.mdpi.com/2673-3943/4/3/13 |
| work_keys_str_mv | AT coreymealer mechanismsofcoldpreservationandreperfusioninjuryforsolidorgantransplantationimplicationsforpartialhearttransplantations AT haleykonsek mechanismsofcoldpreservationandreperfusioninjuryforsolidorgantransplantationimplicationsforpartialhearttransplantations AT zacharytravis mechanismsofcoldpreservationandreperfusioninjuryforsolidorgantransplantationimplicationsforpartialhearttransplantations AT rebeccansuk mechanismsofcoldpreservationandreperfusioninjuryforsolidorgantransplantationimplicationsforpartialhearttransplantations AT taufiekkonradrajab mechanismsofcoldpreservationandreperfusioninjuryforsolidorgantransplantationimplicationsforpartialhearttransplantations |