Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation
It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress pl...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/5/708 |
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| author | Andrea Deledda Giuseppe Annunziata Gian Carlo Tenore Vanessa Palmas Aldo Manzin Fernanda Velluzzi |
| author_facet | Andrea Deledda Giuseppe Annunziata Gian Carlo Tenore Vanessa Palmas Aldo Manzin Fernanda Velluzzi |
| author_sort | Andrea Deledda |
| collection | DOAJ |
| description | It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome? |
| first_indexed | 2024-03-10T11:49:58Z |
| format | Article |
| id | doaj.art-2c8d9edc7d754a94ad83fbeb863c5d85 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T11:49:58Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2c8d9edc7d754a94ad83fbeb863c5d852023-11-21T17:46:08ZengMDPI AGAntioxidants2076-39212021-04-0110570810.3390/antiox10050708Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota ModulationAndrea Deledda0Giuseppe Annunziata1Gian Carlo Tenore2Vanessa Palmas3Aldo Manzin4Fernanda Velluzzi5Obesity Unit, Department of Medical Sciences and Public Health, University of Cagliari, Ospedale San Giovanni di Dio, Via Ospedale 54, 09124 Cagliari, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyMicrobiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, ItalyMicrobiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, ItalyObesity Unit, Department of Medical Sciences and Public Health, University of Cagliari, Ospedale San Giovanni di Dio, Via Ospedale 54, 09124 Cagliari, ItalyIt is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome?https://www.mdpi.com/2076-3921/10/5/708inflammationobesitygut microbiotaoxidative stressantioxidantspolyphenols |
| spellingShingle | Andrea Deledda Giuseppe Annunziata Gian Carlo Tenore Vanessa Palmas Aldo Manzin Fernanda Velluzzi Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation Antioxidants inflammation obesity gut microbiota oxidative stress antioxidants polyphenols |
| title | Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation |
| title_full | Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation |
| title_fullStr | Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation |
| title_full_unstemmed | Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation |
| title_short | Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation |
| title_sort | diet derived antioxidants and their role in inflammation obesity and gut microbiota modulation |
| topic | inflammation obesity gut microbiota oxidative stress antioxidants polyphenols |
| url | https://www.mdpi.com/2076-3921/10/5/708 |
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