Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung
Synthesis of N-4-O-asetilferuloylmorpholine from ferulic acid via indirect conversion methods with acetylation, chlorination and amidation (in situ) reactions have been conducted. The acetylation was carried out using acetic anhydride reagent in pyridine solvent at room temperature for 6 hours. The...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Pattimura University
2016-01-01
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| Series: | Indonesian Journal of Chemical Research |
| Subjects: | |
| Online Access: | https://ojs3.unpatti.ac.id/index.php/ijcr/article/view/128 |
| _version_ | 1818890897564106752 |
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| author | Sabir Sumarna Firdaus Firdaus Nunuk H. Soekamto |
| author_facet | Sabir Sumarna Firdaus Firdaus Nunuk H. Soekamto |
| author_sort | Sabir Sumarna |
| collection | DOAJ |
| description | Synthesis of N-4-O-asetilferuloylmorpholine from ferulic acid via indirect conversion methods with acetylation, chlorination and amidation (in situ) reactions have been conducted. The acetylation was carried out using acetic anhydride reagent in pyridine solvent at room temperature for 6 hours. The chlorination was performed with thionyl chloride in benzene solvent by reflux at 75°C for 4 hours, proceeded by in situ amidation utilizing morpholine in the presence of triethylamine and pyridine using dichloromethane solvent at room temperature. The target molecule as white crystalline solids with m.p. of 91-92°C. Characterization of these compounds was committed by FTIR spectrophotometry. |
| first_indexed | 2024-12-19T17:32:13Z |
| format | Article |
| id | doaj.art-2c93014c9bd24aebb7eb4d91880e2c99 |
| institution | Directory Open Access Journal |
| issn | 2338-5359 2614-2627 |
| language | English |
| last_indexed | 2024-12-19T17:32:13Z |
| publishDate | 2016-01-01 |
| publisher | Department of Chemistry, Pattimura University |
| record_format | Article |
| series | Indonesian Journal of Chemical Research |
| spelling | doaj.art-2c93014c9bd24aebb7eb4d91880e2c992022-12-21T20:12:25ZengDepartment of Chemistry, Pattimura UniversityIndonesian Journal of Chemical Research2338-53592614-26272016-01-0141Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak LangsungSabir Sumarna0Firdaus Firdaus1Nunuk H. Soekamto2Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-IndonesiaSynthesis of N-4-O-asetilferuloylmorpholine from ferulic acid via indirect conversion methods with acetylation, chlorination and amidation (in situ) reactions have been conducted. The acetylation was carried out using acetic anhydride reagent in pyridine solvent at room temperature for 6 hours. The chlorination was performed with thionyl chloride in benzene solvent by reflux at 75°C for 4 hours, proceeded by in situ amidation utilizing morpholine in the presence of triethylamine and pyridine using dichloromethane solvent at room temperature. The target molecule as white crystalline solids with m.p. of 91-92°C. Characterization of these compounds was committed by FTIR spectrophotometry.https://ojs3.unpatti.ac.id/index.php/ijcr/article/view/128N-4-O-asetilferuloylmorpholine, ferulic acid, acetylation, chlorination, amidation |
| spellingShingle | Sabir Sumarna Firdaus Firdaus Nunuk H. Soekamto Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung Indonesian Journal of Chemical Research N-4-O-asetilferuloylmorpholine, ferulic acid, acetylation, chlorination, amidation |
| title | Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung |
| title_full | Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung |
| title_fullStr | Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung |
| title_full_unstemmed | Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung |
| title_short | Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung |
| title_sort | sintesis turunan amida n 4 o asetilferuloilmorfolina dari asam ferulat melalui metode konversi tidak langsung |
| topic | N-4-O-asetilferuloylmorpholine, ferulic acid, acetylation, chlorination, amidation |
| url | https://ojs3.unpatti.ac.id/index.php/ijcr/article/view/128 |
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