<it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population
<p>Abstract</p> <p>Background</p> <p>In adults, the <it>TCF7L2 </it>rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-06-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/8/37 |
| _version_ | 1818900995102474240 |
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| author | Gaget Stefan Durand Emmanuelle Deghmoun Samia Choquet Hélène Meyre David Cauchi Stéphane Lecoeur Cécile Froguel Philippe Levy-Marchal Claire |
| author_facet | Gaget Stefan Durand Emmanuelle Deghmoun Samia Choquet Hélène Meyre David Cauchi Stéphane Lecoeur Cécile Froguel Philippe Levy-Marchal Claire |
| author_sort | Gaget Stefan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In adults, the <it>TCF7L2 </it>rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.</p> <p>Methods</p> <p>The present association study aimed at analyzing the contribution of the rs7903146 SNP to smallness for gestational age (SGA) and metabolic profiles in subjects with SGA or appropriate for gestational age birth weight (AGA). Two groups of French Caucasian subjects were selected on birth data: SGA (birth weight < 10<sup>th </sup>percentile; n = 764), and AGA (25<sup>th </sup>< birth weight < 75<sup>th </sup>percentile; n = 627). Family-based association tests were also performed in 3,012 subjects from 628 SGA and AGA pedigrees.</p> <p>Results</p> <p>The rs7903146 genotypic distributions between AGA (30.7%) and SGA (29.0%) were not statistically different (allelic OR = 0.92 [0.78–1.09], p = 0.34). Family association-based studies did not show a distortion of T allele transmission in SGA subjects (p = 0.52). No significant effect of the T allele was detected on any of the metabolic parameters in the SGA group. However, in the AGA group, trends towards a lower insulin secretion (p = 0.03) and a higher fasting glycaemia (p = 0.002) were detected in carriers of the T allele.</p> <p>Conclusion</p> <p>The <it>TCF7L2 </it>rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.</p> |
| first_indexed | 2024-12-19T20:12:43Z |
| format | Article |
| id | doaj.art-2c95143720f64fb29e30917457305872 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T20:12:43Z |
| publishDate | 2007-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-2c95143720f64fb29e309174573058722022-12-21T20:07:16ZengBMCBMC Medical Genetics1471-23502007-06-01813710.1186/1471-2350-8-37<it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French populationGaget StefanDurand EmmanuelleDeghmoun SamiaChoquet HélèneMeyre DavidCauchi StéphaneLecoeur CécileFroguel PhilippeLevy-Marchal Claire<p>Abstract</p> <p>Background</p> <p>In adults, the <it>TCF7L2 </it>rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.</p> <p>Methods</p> <p>The present association study aimed at analyzing the contribution of the rs7903146 SNP to smallness for gestational age (SGA) and metabolic profiles in subjects with SGA or appropriate for gestational age birth weight (AGA). Two groups of French Caucasian subjects were selected on birth data: SGA (birth weight < 10<sup>th </sup>percentile; n = 764), and AGA (25<sup>th </sup>< birth weight < 75<sup>th </sup>percentile; n = 627). Family-based association tests were also performed in 3,012 subjects from 628 SGA and AGA pedigrees.</p> <p>Results</p> <p>The rs7903146 genotypic distributions between AGA (30.7%) and SGA (29.0%) were not statistically different (allelic OR = 0.92 [0.78–1.09], p = 0.34). Family association-based studies did not show a distortion of T allele transmission in SGA subjects (p = 0.52). No significant effect of the T allele was detected on any of the metabolic parameters in the SGA group. However, in the AGA group, trends towards a lower insulin secretion (p = 0.03) and a higher fasting glycaemia (p = 0.002) were detected in carriers of the T allele.</p> <p>Conclusion</p> <p>The <it>TCF7L2 </it>rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.</p>http://www.biomedcentral.com/1471-2350/8/37 |
| spellingShingle | Gaget Stefan Durand Emmanuelle Deghmoun Samia Choquet Hélène Meyre David Cauchi Stéphane Lecoeur Cécile Froguel Philippe Levy-Marchal Claire <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population BMC Medical Genetics |
| title | <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population |
| title_full | <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population |
| title_fullStr | <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population |
| title_full_unstemmed | <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population |
| title_short | <it>TCF7L2 </it>rs7903146 variant does not associate with smallness for gestational age in the French population |
| title_sort | it tcf7l2 it rs7903146 variant does not associate with smallness for gestational age in the french population |
| url | http://www.biomedcentral.com/1471-2350/8/37 |
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