Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty
Abstract Background The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. Methods Eligible patie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-018-0716-2 |
| _version_ | 1798040855098949632 |
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| author | Ju Tang Wei Zhu Xiaoliang Mei Zhenxiang Zhang |
| author_facet | Ju Tang Wei Zhu Xiaoliang Mei Zhenxiang Zhang |
| author_sort | Ju Tang |
| collection | DOAJ |
| description | Abstract Background The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. Methods Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT. Results A total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04–1.29; p = 0.011). Conclusions Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA. |
| first_indexed | 2024-04-11T22:13:26Z |
| format | Article |
| id | doaj.art-2c9550d986294761a2b7510d627bad1c |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T22:13:26Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-2c9550d986294761a2b7510d627bad1c2022-12-22T04:00:30ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2018-01-011311510.1186/s13018-018-0716-2Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplastyJu Tang0Wei Zhu1Xiaoliang Mei2Zhenxiang Zhang3Department of Joint Surgery, Taizhou People’s Hospital, Medical School of Nantong UniversityDepartment of Joint Surgery, Taizhou People’s Hospital, Medical School of Nantong UniversityDepartment of Joint Surgery, Taizhou People’s Hospital, Medical School of Nantong UniversityDepartment of Joint Surgery, Taizhou People’s Hospital, Medical School of Nantong UniversityAbstract Background The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. Methods Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT. Results A total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04–1.29; p = 0.011). Conclusions Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.http://link.springer.com/article/10.1186/s13018-018-0716-2Total hip arthroplastyDeep vein thrombosisPlasminogen activator inhibitor-1Risk factor |
| spellingShingle | Ju Tang Wei Zhu Xiaoliang Mei Zhenxiang Zhang Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty Journal of Orthopaedic Surgery and Research Total hip arthroplasty Deep vein thrombosis Plasminogen activator inhibitor-1 Risk factor |
| title | Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty |
| title_full | Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty |
| title_fullStr | Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty |
| title_full_unstemmed | Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty |
| title_short | Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty |
| title_sort | plasminogen activator inhibitor 1 a risk factor for deep vein thrombosis after total hip arthroplasty |
| topic | Total hip arthroplasty Deep vein thrombosis Plasminogen activator inhibitor-1 Risk factor |
| url | http://link.springer.com/article/10.1186/s13018-018-0716-2 |
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