Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort.
<h4>Background</h4>The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study.<h4>Objective</h4>To investigate whether serum con...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0269569 |
| _version_ | 1811217406049124352 |
|---|---|
| author | Erla S Sigurðardóttir Thorarinn Gislason Bryndis Benediktsdottir Steinar Hustad Payam Dadvand Pascal Demoly Karl A Franklin Joachim Heinrich Mathias Holm Diana A van der Plaat Rain Jõgi Benedicte Leynaert Eva Lindberg Jesus Martinez-Moratalla Leire Sainz De Aja Giancarlo Pesce Isabelle Pin Chantal Raherison Antonio Pereira-Vega Francisco Gómez Real Kai Triebner |
| author_facet | Erla S Sigurðardóttir Thorarinn Gislason Bryndis Benediktsdottir Steinar Hustad Payam Dadvand Pascal Demoly Karl A Franklin Joachim Heinrich Mathias Holm Diana A van der Plaat Rain Jõgi Benedicte Leynaert Eva Lindberg Jesus Martinez-Moratalla Leire Sainz De Aja Giancarlo Pesce Isabelle Pin Chantal Raherison Antonio Pereira-Vega Francisco Gómez Real Kai Triebner |
| author_sort | Erla S Sigurðardóttir |
| collection | DOAJ |
| description | <h4>Background</h4>The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study.<h4>Objective</h4>To investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population.<h4>Methods</h4>We analyzed data from 774 women (40-67 years) from 15 study centers in seven countries participating in the second follow-up of the European Community Respiratory Health Survey (2010-2012). Multiple logistic regression models were fitted with self-reported symptoms of sleep apnea as outcomes and serum concentrations of various estrogens and progesterone as predictors. All analyses were adjusted for relevant covariates including age, BMI, education, study center, smoking habits, and reproductive age.<h4>Results</h4>Among all included women, a doubling of serum concentrations of estrone and progesterone was associated with 19% respectively 9% decreased odds of snoring. Among snorers, a doubling of the concentrations of 17β-estradiol, estrone and estrone 3-sulfate was associated with 18%, 23% and 17% decreased odds of breathing irregularly, and a doubling of the progesterone concentration was further associated with 12% decreased odds of waking up suddenly with a chocking sensation. Other evaluated associations were not statistically significant.<h4>Conclusions</h4>Middle-aged women with low serum estrogen and progesterone levels are more likely to snore and report symptoms of obstructive sleep apnea. |
| first_indexed | 2024-04-12T06:54:35Z |
| format | Article |
| id | doaj.art-2c96cba80ba045349659184b59d35580 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T06:54:35Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2c96cba80ba045349659184b59d355802022-12-22T03:43:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176e026956910.1371/journal.pone.0269569Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort.Erla S SigurðardóttirThorarinn GislasonBryndis BenediktsdottirSteinar HustadPayam DadvandPascal DemolyKarl A FranklinJoachim HeinrichMathias HolmDiana A van der PlaatRain JõgiBenedicte LeynaertEva LindbergJesus Martinez-MoratallaLeire Sainz De AjaGiancarlo PesceIsabelle PinChantal RaherisonAntonio Pereira-VegaFrancisco Gómez RealKai Triebner<h4>Background</h4>The prevalence of obstructive sleep apnea is higher in women after menopause. This is suggested to be a result of an altered sex hormone balance but has so far not been confirmed in a population-based study.<h4>Objective</h4>To investigate whether serum concentration of estrogens and progesterone are associated with the prevalence of sleep apnea symptoms in middle-aged women of the general population.<h4>Methods</h4>We analyzed data from 774 women (40-67 years) from 15 study centers in seven countries participating in the second follow-up of the European Community Respiratory Health Survey (2010-2012). Multiple logistic regression models were fitted with self-reported symptoms of sleep apnea as outcomes and serum concentrations of various estrogens and progesterone as predictors. All analyses were adjusted for relevant covariates including age, BMI, education, study center, smoking habits, and reproductive age.<h4>Results</h4>Among all included women, a doubling of serum concentrations of estrone and progesterone was associated with 19% respectively 9% decreased odds of snoring. Among snorers, a doubling of the concentrations of 17β-estradiol, estrone and estrone 3-sulfate was associated with 18%, 23% and 17% decreased odds of breathing irregularly, and a doubling of the progesterone concentration was further associated with 12% decreased odds of waking up suddenly with a chocking sensation. Other evaluated associations were not statistically significant.<h4>Conclusions</h4>Middle-aged women with low serum estrogen and progesterone levels are more likely to snore and report symptoms of obstructive sleep apnea.https://doi.org/10.1371/journal.pone.0269569 |
| spellingShingle | Erla S Sigurðardóttir Thorarinn Gislason Bryndis Benediktsdottir Steinar Hustad Payam Dadvand Pascal Demoly Karl A Franklin Joachim Heinrich Mathias Holm Diana A van der Plaat Rain Jõgi Benedicte Leynaert Eva Lindberg Jesus Martinez-Moratalla Leire Sainz De Aja Giancarlo Pesce Isabelle Pin Chantal Raherison Antonio Pereira-Vega Francisco Gómez Real Kai Triebner Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. PLoS ONE |
| title | Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. |
| title_full | Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. |
| title_fullStr | Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. |
| title_full_unstemmed | Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. |
| title_short | Female sex hormones and symptoms of obstructive sleep apnea in European women of a population-based cohort. |
| title_sort | female sex hormones and symptoms of obstructive sleep apnea in european women of a population based cohort |
| url | https://doi.org/10.1371/journal.pone.0269569 |
| work_keys_str_mv | AT erlassigurðardottir femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT thorarinngislason femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT bryndisbenediktsdottir femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT steinarhustad femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT payamdadvand femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT pascaldemoly femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT karlafranklin femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT joachimheinrich femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT mathiasholm femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT dianaavanderplaat femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT rainjogi femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT benedicteleynaert femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT evalindberg femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT jesusmartinezmoratalla femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT leiresainzdeaja femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT giancarlopesce femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT isabellepin femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT chantalraherison femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT antoniopereiravega femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT franciscogomezreal femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort AT kaitriebner femalesexhormonesandsymptomsofobstructivesleepapneaineuropeanwomenofapopulationbasedcohort |