The transcriptional response to tumorigenic polarity loss in Drosophila

The transcriptional response to tumorigenic polarity loss in Drosophila

Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic inve...

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Bibliographic Details
Main Authors: Brandon D Bunker, Tittu T Nellimoottil, Ryan M Boileau, Anne K Classen, David Bilder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
tumor
cancer
epithelial cell
transcriptome
polarity
Online Access:https://elifesciences.org/articles/03189

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